“…In addition, as suggested by Rodriguez and authors [15], the distribution of aneurysm locations in the ISAT study is significantly different from what was previously reported, with MCA aneurysms comprising only 14.0 % of all aneurysms in ISAT as compared to approximately 25.0 % in reported literature, suggesting a potential sampling bias that favors maximizing outcome in the coiling group. Furthermore, current available comparative studies and meta-analyses on MCA aneurysm treatment suggested slight to moderate advantage of clipping over coiling [24,30,31,42]. Therefore, further investigation is warranted for justification of endovascular therapy as a viable alternative to surgical therapy in definitive treatment of MCA aneurysms.…”