Endovascular interventions are increasing to meet the clinical demands of modern peripheral arterial disease patients

Marron, Conor; Fitridge, Robert

doi:10.1111/ans.15121

Cited by 1 publication

(1 citation statement)

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“…Peripheral arterial disease (PAD) affects 10%-20% of people worldwide and the incidence of PAD increases with age [1][2][3]. Endovascular interventions with stents are the main treatment for patients with PAD [4,5]. Instent restenosis (ISR) has become a major challenge for patients received stents: ISR has been reported to occur in 30%-40% of patients with PAD within two to three years of treatment [6].…”

Section: Introductionmentioning

confidence: 99%

A Novel Sirolimus-eluting Biodegradable Magnesium-based Alloy Scaffold: Six-month Results In Porcine Peripheral Arteries

Liu

Zhang

et al. 2021

CIM

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Purpose: Magnesium-based alloy scaffold is a promising biodegradable stent due to its intrinsic mechanical performance and biocompatibility. Based on our preliminary experiments, we designed a novel sirolimus-eluting magnesium-based alloy scaffold. This work aimed to assess its safety and degradation performance in vivo. Methods: The scaffolds were implanted in the lower limb arteries of Bama mini-pigs. Safety was defined as no immediate thrombosis or >30% residual stenosis, which was assessed with optical coherence tomography and digital subtraction angiography. Blood biochemical analyses were performed to evaluate hepatorenal toxicity. The degradation process of the scaffolds, the endothelialization, and lumen loss of the stented-vessels were detected with scanning electron microscopy, immunohistochemical, hematoxylin-eosin staining and optical coherence tomography. Results: Twenty-four scaffolds were successfully implanted in six pigs with no signs of immediate thrombosis or >30% residual stenosis. The scaffolds were covered by endothelium at one month and absolutely resorbed at six months post implantation. Blood analysis showed that the hepatorenal function except for alanine aminotransferase and γ-glutamyl transpeptidase was normal. Obvious intimal hyperplasia and lumen loss were found in the stented vessels at three months, while the diameters and inner lumen areas of stented segments had increased significantly at six months (p

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