Endpoints for multimodal clinical trials in Stage III non-small cell lung cancer (NSCLC): a consensus report

Green, M.R.; Cox, James D.; Ardizzoni, Andrea; Arriagada, R.; Bureau, G.; Darwish, Samir; Deneffe, G.; Fukuoka, M.; Joseph, D.; Komaki, Ritsuko; Mirimanoff, R.O.; Mornex, F.; Palazzi, M.; Pastorino, Ugo; Pavy, JJ; Postmus, Pieter E.; Roth, Joshua D.; Rubin, P.; Saijo, N; Saunders, Michele I.; Stout, Ronald; Sutedja, Tom G.; Trovò, M.

doi:10.1016/0169-5002(94)91859-7

Cited by 31 publications

(8 citation statements)

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“…Other investigators have focussed on an early intensification of preoperative downstaging by so-called "bimodality induction", including chemotherapy as well as radiation therapy prior to surgery [11][12][13][14]. This approach seems to be especially attractive for more locally advanced selected IIIB subgroups, where a maximum of preoperative downstaging is mandatory in order to enable a complete resection of any vital tumour, left after induction -mostly at areas of bulky disease in the primary tumour or the mediastinum.…”

Section: Discussionmentioning

confidence: 97%

Surgery after multimodality treatment for non-small-cell lung cancer

Stamatis

Eberhard²,

Pöttgen³

2004

Lung Cancer

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Section: Discussionmentioning

confidence: 97%

Surgery after multimodality treatment for non-small-cell lung cancer

Stamatis

Eberhard²,

Pöttgen³

2004

Lung Cancer

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“…Local tumor control was evaluated according to the criteria of Green et al (27). An isolated nodal recurrence was defined as recurrence in the regional nodes outside the CTV, in the absence of in-field failure or distant metastases.…”

Section: Post-treatment Follow-upmentioning

confidence: 99%

Selective Nodal Irradiation on Basis of 18FDG-PET Scans in Limited-Disease Small-Cell Lung Cancer: A Prospective Study

Loon

Ruysscher

Wanders

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

168

105

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PET-based selective nodal irradiation for LD-SCLC resulted in a low rate of isolated nodal failures (3%), with a low percentage of acute esophagitis. These findings are in contrast to those from our prospective study of CT-based selective nodal irradiation, which resulted in an unexpectedly high percentage of isolated nodal failures (11%). Because of the low rate of isolated nodal failures and toxicity, we believe that our data support the use of PET-based SNI for LD-SCLC.

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“…Patients still alive were censored from the date of last information. Event-free survival was calculated from the start of therapy until the appearance of a local progression, distant metastases, secondary tumor, or death from every cause [15]. Patients without events were censored from the date of last information.…”

Section: Statisticsmentioning

confidence: 99%