INTRODUCTION: In today's world, Wireless Body Area Networks (WBAN) has emanated as a budding field within the healthcare scenario for monitoring, detecting, predicting, and diagnosing various fatal diseases such as cancer, cardiovascular, diabetes and other infectious diseases such as tuberclosis, pneumonia and ebola. It is an assemblage of bio-sensors which could be put on or embedded in a patient's body to surveil the functionality of various body organs. OBJECTIVES: The purpose of that proposed protocol is to select the relay node and record the various physiological parameters like body temperature, blood pressure, rate of blood sugar of human being. Energy consumption is a major hurdle in WBAN as replacing as well as recharging the nodes pinioned to human body may bring about discomfort to the patient. Therefore, in this work, the emphasis is given to improve the performance of WBAN i.e. network lifetime, greater mobility, stability and energy efficiency. METHODS: To find the shortest energy-efficient route and avoid any kind of relay node failure, a novel routing scheme called Enhanced Opportunistic Protocol using Relay nodes (E-OPR) is proposed for data routing. CONCLUSION: Finally, an enhanced opportunistic protocol using relay node in WBAN has been proposed for cost effective real time health monitoring system. The proposed solution seems to give better results as compare single-hop, multi-hop routing protocols in terms of throughput, network lifetime, energy consumption and path loss.