Innovative Internet of Things (IoT) applications with strict performance and energy consumption requirements and where the agile collection of data is paramount are arising. Wireless sensor networks (WSNs) represent a promising solution as they can be easily deployed to sense, process, and forward data. The large number of Sensor Nodes (SNs) composing a WSN are expected to be autonomous, with a node’s lifetime dictated by the battery’s size. As the form factor of the SN is critical in various use cases, minimizing energy consumption while ensuring availability becomes a priority. Moreover, energy harvesting techniques are increasingly considered as a viable solution for building an entirely green SN and prolonging its lifetime. In the process of building a SN and in the absence of a clear and well-rounded methodology, the designer can easily make unfounded and suboptimal decisions about the right hardware components, their configuration, and reliable data communication techniques, such as automatic repeat request (ARQ) and forward error correction (FEC). In this paper, a methodology to design, configure, and deploy a reliable ultra-low power WSNs is proposed. A comprehensive energy model and a realistic path-loss (PL) model of the sensor node are also established. Through estimations and field measurements it is proven that, following the proposed methodology, the designer can thoroughly explore the design space and the make most favorable decisions when choosing commercial off-the-shelf (COTS) components, configuring the node, and deploying a reliable and energy-efficient WSN.