Energy homeostasis in rabbit does during pregnancy and pseudopregnancy

Menchetti, Laura; Andoni, Egon; Barbato, Olimpia; Canali, C.; Quattrone, Alda; Vigo, D.; Codini, Michela; Curone, Giulio; Brecchia, G.

doi:10.1016/j.anireprosci.2020.106505

Cited by 13 publications

(18 citation statements)

References 41 publications

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“…Maintaining this balance is never easy and, in fact, there are frequent alterations that lead to pathological conditions such as obesity and diabetes. During pregnancy, energy homeostasis is even more complicated because the body must also ensure the growth of the foetus and prepare for the next lactation [27,31,32]. The energy balance during a reproduction cycle is one of the most problematic issues for rabbit breeding because it has consequences not only on the animal welfare but also on the profitability of the farm [28,29].…”

Section: Discussionmentioning

confidence: 99%

“…These hormones and metabolites have recently been evaluated by Menchetti et al [31] in pregnant and pseudopregnant rabbits. However, this previous study focused on changes during the 32 days post insemination, the sampling was weekly, and no observations were done after the birth.…”

Section: Discussionmentioning

confidence: 99%

“…The metabolites glucose and NEFA were assayed by colorimetric methods according to Menchetti et al [31], and García-García et al [35] respectively. The NEFA plasma concentrations were evaluated using a colorimetric assay from Wako that use two enzymatic reactions (NEFA-C, Wako Chemicals GmbH, Neuss, Germany), and based on the ability of NEFA to acylate coenzyme A in the presence of CoA synthetase.…”

Section: Hormone and Metabolite Assaysmentioning

confidence: 99%

“…Finally, the homeostasis model assessment for insulin resistance (HOMA) was used as index of insulin-resistance and it was calculated using a formula previously reported [27,31]: [insulin concentration × (glucose concentration/18)]/22.5. Insulin resistance (low insulin sensibility) is evident when the HOMA-IR is high while low HOMA-IR values are expression of high insulin sensitivity.…”

Section: Hormone and Metabolite Assaysmentioning

confidence: 99%

“…In fact, during this physiological status, the pregnant animal enhances the feed intake and the mobilization of the body reserves as an adaption mechanisms to the modification in energetic request [26][27][28]. Different hormones (insulin, leptin, T3, T4 and cortisol) and metabolites such as glucose and non-esterified fatty acids (NEFA) are implicated in maintaining energy homeostasis during pregnancy in different species [29][30][31][32]. To our knowledge, no studies have evaluated the impact of the goji berries enriched diet on the hormonal control of the energetic homeostasis during pregnancy of the rabbit does.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Goji Berries (Lycium barbarum) Supplementation on the Energy Homeostasis of Rabbit Does: Uni- and Multivariate Approach

Menchetti

Curone

Andoni

et al. 2020

Animals

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This study examined the effects of goji berries dietary supplementation on the energetic metabolism of doe. Thirty days before artificial insemination, 75 New Zealand White does were assigned to three different diets: commercial standard diet (C) and supplemented with 1% (LG) and 3% (HG) of goji berries, respectively. Body conditions, hormones and metabolites were monitored until weaning. Body weight and BCS were higher in HG than C (p < 0.05). LG showed lower T3/T4 ratio and cortisol concentrations (p < 0.05) and tended to have lower indices of insulin resistances (p < 0.1) than HG. Compared to control, leptin was higher in HG at AI (p < 0.01) and in LG during lactation (p < 0.05). Two principal components were extracted by multivariate analysis describing the relationships between (1) non-esterified fatty acids, insulin and glucose levels, and (2) body conditions and leptin metabolism. The first component highlighted the energy deficit and the insulin resistance of the does during pregnancy and lactation. The second one showed that leptin, body weight and Body Condition Score (BCS) enhance as levels of goji berries in the diet increase. Thus, the effects of goji supplementation are dose-dependent: an improvement on energy metabolism was achieved with a low-dose while the highest dose could determine excessive fattening and insulin resistance in does.

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