The Qinghai–Tibet plateau, with an average altitude of over 4000 m, has low annual average temperatures and a high demand for building heating. This region’s abundant solar energy resources hold substantial practical significance for improving the indoor heat environment and reducing building energy consumption. This paper investigates the impact of orientation and skylight area ratio on building heat load and indoor temperature, using both actual measurement and simulation methods, with a case study of the comprehensive building at Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment (Beiluhe Station), located in the Qinghai–Tibet Plateau region. Initially, a model was established using the EnergyPlus 9.4 software, with orientation variables set from east to west in 15° increments, to simulate the variations in building heat load resulting from orientation changes; simulations were then conducted for three different skylight area ratios under the optimal orientation to evaluate their influence on heat load and indoor temperature. The results show that for the architectural style examined in this paper, the optimal building orientation within the region is 30° south by east, with the optimal orientation range spanning from 45° south by east to due south. Heating load is negatively correlated with the skylight area ratio, and beyond a certain threshold, the rate of decrease in heat load diminishes or even stabilizes. The conclusions of this paper offer guidance for the orientation and skylight design of new buildings on the Qinghai–Tibet Plateau.