Water, energy and food are the basic resources for human survival and development. The coordination development of water-energy-food (W-E-F) is of great significance to promote regional sustainable development. In this study, Northwest China (Shaanxi, Gansu, Qinghai, Ningxia, Xinjiang) was selected as the research case, and an evaluation index system was constructed to assess the vulnerability and coordination of water-energy-food (W-E-F) system based on PSR model. Then, a coupled model based on cloud-matter element model and coordination degree model was proposed. The cloud-matter element model was adopted to evaluate the vulnerability level of W-E-F system. The coordination degree model was employed to calculate the coordination degrees of W-E-F system. The results showed that, from 2006 to 2015, the vulnerability levels of W-E-F system in Northwest China were mostly at Level 1. The coordination degrees of W-E-F system belonged to the transitional development level (II) in most years. The vulnerability and coordination problems of W-E-F system in Northwest China were severe. The comprehensive vulnerability index values of W-E-F system were generally on the rise, but far from reaching a good level. Moreover, the comprehensive vulnerability index values and coordination degrees of W-E-F system in Northwest China do not match well. Finally, the countermeasures and suggestions to improve the coordinated development of water resource, energy and food in Northwest China were put forward.2 of 25 scholars and relevant departments. Research on W-E-F system has become an important topic in the field of sustainable development [4].Vulnerability, as an important research object, has been put on the research agenda by international scientific programs and institutions such as IHDP, IPCC, IGBP [5][6][7]. It has become the frontier and hotspot of global environmental change and sustainable scientific research. In 1999, the United Nations Development Programme (UNDP) formally put forward the concept of "economic vulnerability" [8]. After that, the research object of vulnerability has gradually expanded from the natural ecological environment system to the complex system which includes the natural, social, economic and institutional factors. Cutter [9] summarized the related concepts of vulnerability, pointing out that social vulnerability is a natural risk and social response within a specific region or geographical scope, and stressing the imbalance of social preparedness, response, recovery and adaptation to disasters. The United Nations International Strategy for Disaster Reduction (UNISDR) defined vulnerability as the extent to which the attributes of communities, systems or property and the environment are damaged by disaster-causing factors. It was considered that vulnerability was related to various natural, social, economic and environmental factors, and has certain temporal and spatial attributes [10]. Chen et al. [11] indicated that social vulnerability influenced people's ability to make full pre-disaster preparatio...