Abstract:Due to the high incidence of diabetes mellitus (DM) and poor response to the first-line treatment of DM-induced erectile dysfunction (DMED), new therapeutic strategies for DMED are needed. Adipose-derived stem cell (ADSC) transplantation is considered a promising treatment modality for DMED but is limited by poor survival and efficacy after transplantation. In this study, we aimed to increase the therapeutic effect of DMED by overexpressing the relaxin family peptide receptor 1 (RXFP1) using a clustered regula… Show more
“… 49 , 50 Research on ECs and SMCs was ongoing until 2022, signifying that normalization of these two components in the corpus cavernosum was critical to erection. 19 , 20 , 41 Figure 7 Visualization results of keywords on the research of SCT for ED. ( A ) Co-occurrence analysis of keywords.…”
Section: Resultsmentioning
confidence: 99%
“…28), indicating that this is a popular journal for research in this field. It was followed by the International Journal of Impotence Research (28), Andrology (20), Asian Journal of Andrology (18), and Translational Andrology and Urology (14), which are all professional journals related to urology and andrology. Moreover, the 2022 impact factors (IF) of these journals were all slightly low, ranging from 2.5 to 5.5, which may be limited by the average IF level of professional journals in the field of andrology.…”
Section: Analysis Of Authorsmentioning
confidence: 99%
“… 11 , 17 , 18 More importantly, stem cells can alleviate not only symptoms but also ED by addressing pathological mechanisms, including differentiating into specific effector cells and secreting numerous growth factors and exosomes, thereby improving the local pathological environment and stimulating tissue repair. 16 , 19 , 20 …”
Section: Introductionmentioning
confidence: 99%
“…11,17,18 More importantly, stem cells can alleviate not only symptoms but also ED by addressing pathological mechanisms, including differentiating into specific effector cells and secreting numerous growth factors and exosomes, thereby improving the local pathological environment and stimulating tissue repair. 16,19,20 While many studies have contributed to the basic research and clinical translation of SCT in ED treatment, researchers are typically unable to quickly grasp current research progress, frontiers, and future development directions in this field based on the complicated literature. Traditional literature reviews are generally associated with a certain degree of subjectivity and one-sidedness, and cannot comprehensively and systematically elucidate the above questions.…”
Purpose
As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The purpose of this study is to comprehensively analyze the research of SCT for ED and understand the development trends and research frontiers in this field.
Methods
Publications regarding SCT and ED were retrieved and collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were then utilized for bibliometric and visualization analysis.
Results
A total of 524 publications were eventually included in this study. The annual number of publications in this field was increasing year by year. China and the USA were the two most productive countries. Lin GT, Lue TF and Lin CS, and the University of California San Francisco where they worked were the most productive research group and institution, respectively. The journal with the largest number of publications was The Journal of Sexual Medicine, and the following were mostly professional journals of urology and andrology. Diabetes mellitus-induced ED and cavernous nerve injury-related ED were the two most commonly constructed models of ED in studies. Concerning the types of stem cells, mesenchymal stem cells derived from adipose and bone marrow were most frequently used. Moreover, future research would mainly focus on exosomes, tissue engineering technology, extracorporeal shockwave therapy, and clinical translation.
Conclusion
The research of SCT for ED will receive increasing global attention in the future. Our study provided bibliometric and visualization analysis of published literature, helping researchers understand the global landscape and frontiers in this field. More preclinical and clinical studies should be conducted to more deeply explore the underlying mechanisms of treatment and promote clinical translation.
“… 49 , 50 Research on ECs and SMCs was ongoing until 2022, signifying that normalization of these two components in the corpus cavernosum was critical to erection. 19 , 20 , 41 Figure 7 Visualization results of keywords on the research of SCT for ED. ( A ) Co-occurrence analysis of keywords.…”
Section: Resultsmentioning
confidence: 99%
“…28), indicating that this is a popular journal for research in this field. It was followed by the International Journal of Impotence Research (28), Andrology (20), Asian Journal of Andrology (18), and Translational Andrology and Urology (14), which are all professional journals related to urology and andrology. Moreover, the 2022 impact factors (IF) of these journals were all slightly low, ranging from 2.5 to 5.5, which may be limited by the average IF level of professional journals in the field of andrology.…”
Section: Analysis Of Authorsmentioning
confidence: 99%
“… 11 , 17 , 18 More importantly, stem cells can alleviate not only symptoms but also ED by addressing pathological mechanisms, including differentiating into specific effector cells and secreting numerous growth factors and exosomes, thereby improving the local pathological environment and stimulating tissue repair. 16 , 19 , 20 …”
Section: Introductionmentioning
confidence: 99%
“…11,17,18 More importantly, stem cells can alleviate not only symptoms but also ED by addressing pathological mechanisms, including differentiating into specific effector cells and secreting numerous growth factors and exosomes, thereby improving the local pathological environment and stimulating tissue repair. 16,19,20 While many studies have contributed to the basic research and clinical translation of SCT in ED treatment, researchers are typically unable to quickly grasp current research progress, frontiers, and future development directions in this field based on the complicated literature. Traditional literature reviews are generally associated with a certain degree of subjectivity and one-sidedness, and cannot comprehensively and systematically elucidate the above questions.…”
Purpose
As a common male disease, erectile dysfunction (ED) seriously affects the physical and mental health of patients. In recent years, studies have continued to point out the great potential of stem cell therapy (SCT) in the treatment of ED. The purpose of this study is to comprehensively analyze the research of SCT for ED and understand the development trends and research frontiers in this field.
Methods
Publications regarding SCT and ED were retrieved and collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were then utilized for bibliometric and visualization analysis.
Results
A total of 524 publications were eventually included in this study. The annual number of publications in this field was increasing year by year. China and the USA were the two most productive countries. Lin GT, Lue TF and Lin CS, and the University of California San Francisco where they worked were the most productive research group and institution, respectively. The journal with the largest number of publications was The Journal of Sexual Medicine, and the following were mostly professional journals of urology and andrology. Diabetes mellitus-induced ED and cavernous nerve injury-related ED were the two most commonly constructed models of ED in studies. Concerning the types of stem cells, mesenchymal stem cells derived from adipose and bone marrow were most frequently used. Moreover, future research would mainly focus on exosomes, tissue engineering technology, extracorporeal shockwave therapy, and clinical translation.
Conclusion
The research of SCT for ED will receive increasing global attention in the future. Our study provided bibliometric and visualization analysis of published literature, helping researchers understand the global landscape and frontiers in this field. More preclinical and clinical studies should be conducted to more deeply explore the underlying mechanisms of treatment and promote clinical translation.
“…There is a growing interest in carrying out human adipose tissue grafting by using adipose stem cells or progenitors due to their resistance to trauma and long-term survival following transplantation. One such example, is the use of CRISPRa to upregulate the relaxin family peptide receptor 1 ( RXFP1 ) in adipose-derived stem cells and their transplantation in a diabetes mellitus induced erectile dysfunction rat model, showing amelioration of the erectile disfunction phenotype ( 51 ). Organoids could be advantageous for these cells as they provide a 3D-culture that can better recapitulate the heterogeneity of adipose tissue, respond better to endogenous stimuli and form tissue microenvironments that could more efficiently integrate with cancer cells following transplantation.…”
Tumors acquire an increased ability to obtain and metabolize nutrients. Here, we engineered and implanted adipocytes to outcompete tumors for nutrients and show that they can substantially reduce cancer progression. Growing cells or xenografts from several cancers (breast, colon, pancreas, prostate) alongside engineered human adipocytes or adipose organoids significantly suppresses cancer progression and reduces hypoxia and angiogenesis. Transplanting modulated adipocyte organoids in pancreatic or breast cancer mouse models nearby or distal from the tumor significantly suppresses its growth. To further showcase therapeutic potential, we demonstrate that co-culturing tumor organoids derived from human breast cancers with engineered patient-derived adipocytes significantly reduces cancer growth. Combined, our results introduce a novel cancer therapeutic approach, termed adipose modulation transplantation (AMT), that can be utilized for a broad range of cancers.
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