Engineered cellular response to scaffold architecture in a rabbit trephine defect

Simon, Jean-Pierre; Roy, T. Dutta; Parsons, J. R.; Rekow, E. Dianne; Thompson, Van P.; Kemnitzer, John E.; Ricci, John L.

doi:10.1002/jbm.a.10569

Cited by 88 publications

(69 citation statements)

References 22 publications

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“…Many studies have stated that an optimal scaffold for bone replacement should have a 3D geometry similar of that of the ingrowing trabecular bone, because it may be an effective approach for fast and efficient conduction of new bone across significant distances in these osteoconductive structures [11,12,13].The importance of the pore size and architecture for a scaffold relies on the fact that they are essential for controlling metabolic aspects such as the diffusion of oxygen, growth factors, and nutrients to the cells [14].…”

Section: Discussionmentioning

confidence: 99%

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

et al. 2014

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Additive manufacture techniques using concentrated colloidal inks are a promising approach for creating three-dimensional (3D) calcium phosphates scaffolds for bone repair and regeneration. Among those, the direct-write assembly allows building scaffolds with precise size and geometry. In the present work, commercial β-TCP and HA were used to produce two types of colloidal ink. According to the ink composition used to build the scaffolds, two different groups were obtained. Group I: scaffolds produced with β-TCP-based ink; and Group II: scaffolds produced with biphasic CaP-based ink (BCP). The 3D scaffolds were assembled in a cylindrical shape (Φ = 8mm x H= 16 mm) with interconnected pore channels of approximately 500μm by robotic deposition of 64 layers using a robocasting machine. The mechanical compression property of the scaffolds was determined using universal testing machine. To assure the controlled geometry of the scaffolds, digital images were obtained by reconstructing each individual scan obtained with a micro-computed tomography. An optical contact angle measurement system was used to evaluate the wettability of the materials. After analyzing the results it was concluded that: the robocasting system is suitable for building 3D periodic calcium phosphates scaffolds; the direct-write assembly didn't change the hydrophilic characteristic of CaPs; and presented mean compressive strength around 11 MPa (β-TCP group) and 15 MPa (BCP group), which is compatible with trabecular bone.

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Section: Discussionmentioning

confidence: 99%

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

et al. 2014

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“…88 The CAD data guides the UV beam onto the liquid surface, which is then lowered to enable the liquid photopolymer to cover the surface. 3DP 89 involves ink jet printing of a binder onto a ceramic, 23,87 polymer 25,31,74,88,117,119,124 or composite 86,93,97 powder surface, one layer at a time. The movement of the jet head, which dispenses the binder, is controlled by the CAD crosssectional data.…”

Section: Introductionmentioning

confidence: 99%

Diffusion in Musculoskeletal Tissue Engineering Scaffolds: Design Issues Related to Porosity, Permeability, Architecture, and Nutrient Mixing

2004

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The field of tissue engineering continues to advance with the discovery of new biomaterials, growth factors and scaffold fabrication techniques. However, for the ultimate success of a tissue engineered construct the issue of nutrient transport to the scaffold interior needs to be addressed. Often, the requirements for adequate nutrient supply are at odds with other scaffold design parameters such as mechanical properties as well as scaffold fabrication techniques, leading to incongruities in finding optimal solutions. The goal of this review article is to provide an overview of the various engineering design factors that promote movement of nutrients, waste and other biomolecules in scaffolds for musculoskeletal tissue engineering applications. The importance of diffusion in scaffolds and how it is influenced by porosity, permeability, architecture, and nutrient mixing has been emphasized. Methods for measuring porosity and permeability have also been outlined. The different types of biomaterials used, scaffold fabrication techniques implemented and the pore sizes/porosities obtained over the past 5 years have also been addressed.

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“…Simon et al showed that geometrical parameters (pore size and the spatial arrangement of pores) affect the pattern of bone ingrowth [38]. The ability to vary and control the level of the three different types of porosity (i.e.…”

Section: Scaffold Architecturementioning

confidence: 99%

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

Sachot¹,

Engel²,

Castaño

2014

COC

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Abstract:The introduction of hybrid materials in regenerative medicine has solved some problems related to the mechanical and bioactive properties of biomaterials. Calcium phosphates and their derivatives have provided the basis for inorganic components, thanks to their good bioactivity, especially in bone regeneration. When mixed with biodegradable polymers, the result is a synergic association that mimics the composition of many tissues of the human body and, additionally, exhibits suitable mechanical properties. Together with the development of nanotechnology and new synthesis methods, hybrids offer a promising option for the development of a third or fourth generation of smart biomaterials and scaffolds to guide the regeneration of natural tissues, with an optimum efficiency/cost ratio. Their potential bioactivity, as well as other valuable features of hybrids, open promising new pathways for their usein bone regeneration and other tissue repair therapies. This review provides a comprehensive overview of the different hybrid organic-inorganic scaffolding bio-materials developed so far for regenerative therapies, especially in bone. It also looks at the potential for research into hybrid materials for other, softer tissues, which is still at an initial stage, but with very promising results.

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Engineered cellular response to scaffold architecture in a rabbit trephine defect

Cited by 88 publications

References 22 publications

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

Direct-write assembly of 3D scaffolds using colloidal calcium phosphates inks

Diffusion in Musculoskeletal Tissue Engineering Scaffolds: Design Issues Related to Porosity, Permeability, Architecture, and Nutrient Mixing

Hybrid Organic-Inorganic Scaffolding Biomaterials for Regenerative Therapies

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