Engineered Fibronectin Peptide Resists Elastase Digestion, Speeds Healing, and Attenuates Scarring in Porcine Burns

Lin, Fubao; Prasad, Atulya; Weber‐Fishkin, Samantha; Clark, Richard A.F.

doi:10.1016/j.jid.2019.10.021

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…The greatest advantage of FN is that it can be used as an alternative therapeutic target. [24][25][26] Previously, we successfully expressed two heparin-bound domain functional peptides at the n-terminal and c-terminal of fibronectin using genetic engineering technology. We also demonstrated that the recombinant fibronectin polypeptide antagonizes hepatic failure induced by endotoxin in mice, 27 these polypeptides were shown to improve the prognosis of sepsis as well as inhibit liver cancer cell metastasis in mice.…”

Section: Introductionmentioning

confidence: 99%

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Plasma fibronectin can affect the cytokine profile and monocytes/macrophages function in addition to predicting the prognosis of advanced sepsis

Yuan

Lin

et al. 2022

The FASEB Journal

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The value of plasma fibronectin (pFN) in the diagnosis and prognosis of sepsis has not been fully established. Previous studies finding that pFN is significantly reduced in sepsis, however, whether reduced pFn affects the prognosis of sepsis has not been clarified. Here, we detected and analyzed pFN and other conventional inflammatory markers in advanced sepsis patients and performed correlation analysis with SOFA score. We also used Fn gene conditional knockout mice which were performed by cecum ligation and puncture (CLP) to investigate the effect of FN deficiency on sepsis prognosis. We found, compared with procalcitonin, c‐reactive protein, and interleukin‐6, pFN was more correlated with SOFA score in advanced sepsis patients (r −.720, p < .001). In animal experiments, Fn gene knockout mice showed significantly greater mortality after CLP compared with the control group because of inhibited phagocytosis and bacterial clearance ability of macrophages, with double cytokine storm. Furthermore, FN can regulate macrophages through the integrin α5β1/Fak/Src signaling pathway. Overall, we found pFN can more accurately reflect the severity and prognosis of advanced sepsis. The absence of FN altered the cytokine storm and phagocytic function of macrophages, suggesting that FN could be a potential therapeutic target in sepsis.

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Section: Introductionmentioning

confidence: 99%

“…The greatest advantage of FN is that it can be used as an alternative therapeutic target 24–26 . Previously, we successfully expressed two heparin‐bound domain functional peptides at the n‐terminal and c‐terminal of fibronectin using genetic engineering technology.…”

Section: Introductionmentioning

confidence: 99%

Plasma fibronectin can affect the cytokine profile and monocytes/macrophages function in addition to predicting the prognosis of advanced sepsis

Yuan

Lin

et al. 2022

The FASEB Journal

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Pharmaceutical Prophylaxis of Scarring with Emphasis on Burns: A Review of Preclinical and Clinical Studies

Leung

2022

Advances in Wound Care

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Future Opportunities in the Field of Drug Delivery Research

Kohn,

Michniak-Kohn

2023

JMS

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Much of the priorities in drug delivery research are focused on targeted drug delivery for cancer therapies and a wide range of controlled drug release systems for commonly used active pharmaceutical ingredients (APIs). In this “thousand words article” we highlight some of the emerging health threats and future opportunities for drug delivery research. Important emerging health threats include viral pandemics beyond COVID, antibiotic-resistant pathogens, the need for new antifungal therapies, and emerging diseases caused by increasing pollution and climate change. Fundamentally new drugs may be needed. For example, one little known research effort focuses on the development of new antibiotics based on metal-organic frameworks. Finally, new delivery approaches will be needed. This is illustrated by the development of a topical peptide delivery system as a wound dressing for burn patients, combining biotechnology (a new peptide) with polymer science (a new topical delivery system) to address a medical need (burn injury) for which there is currently no effective treatment. Another important trend is the shift in our collective understanding of impact, moving away from “counting papers” to considering the societal benefit of the research including its potential for commercialization. To remain relevant in the coming decade, we need to anticipate and embrace future challenges. This is particularly important for younger scientists.

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Engineered Fibronectin Peptide Resists Elastase Digestion, Speeds Healing, and Attenuates Scarring in Porcine Burns

Cited by 3 publications

References 9 publications

Plasma fibronectin can affect the cytokine profile and monocytes/macrophages function in addition to predicting the prognosis of advanced sepsis

Plasma fibronectin can affect the cytokine profile and monocytes/macrophages function in addition to predicting the prognosis of advanced sepsis

Pharmaceutical Prophylaxis of Scarring with Emphasis on Burns: A Review of Preclinical and Clinical Studies

Future Opportunities in the Field of Drug Delivery Research

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