Engineered functional doped hydroxyapatite coating on titanium implants for osseointegration

Li, Jingxuan; Zhang, Tianyu; Liao, Ziming; Wei, Yan; Hang, Ruiqiang; Huang, Di

doi:10.1016/j.jmrt.2023.09.239

Cited by 23 publications

(3 citation statements)

References 219 publications

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“…in a physiological environment typically contains various trace e Cu, Mg, Sr, Ag, Zn, and Fe, which aid bone regeneration [159,160 The introduction of necessary elements into the HA structur cal activity is appealing due to its compact process and simple com conclusions derived from research on HA biomineralisation req [161]. From an engineering standpoint, the main challenge is to ob ture of a specific element that facilitates a long-term and slow r required by the body [162].…”

Section: Hydroxyapatite (Ha)mentioning

confidence: 99%

See 1 more Smart Citation

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Stafin,

Śliwa,

Piątkowski

2023

IJMS

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The alveolar bone is a unique type of bone, and the goal of bone tissue engineering (BTE) is to develop methods to facilitate its regeneration. Currently, an emerging trend involves the fabrication of polycaprolactone (PCL)-based scaffolds using a three-dimensional (3D) printing technique to enhance an osteoconductive architecture. These scaffolds are further modified with hydroxyapatite (HA), type I collagen (CGI), or chitosan (CS) to impart high osteoinductive potential. In conjunction with cell therapy, these scaffolds may serve as an appealing alternative to bone autografts. This review discusses research gaps in the designing of 3D-printed PCL-based scaffolds from a biomimetic perspective. The article begins with a systematic analysis of biological mineralisation (biomineralisation) and ossification to optimise the scaffold’s structural, mechanical, degradation, and surface properties. This scaffold-designing strategy lays the groundwork for developing a research pathway that spans fundamental principles such as molecular dynamics (MD) simulations and fabrication techniques. Ultimately, this paves the way for systematic in vitro and in vivo studies, leading to potential clinical applications.

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Section: Hydroxyapatite (Ha)mentioning

confidence: 99%

“…However, the conclusions derived from research on HA biomineralisation require further clarification [161]. From an engineering standpoint, the main challenge is to obtain HA with an admixture of a specific element that facilitates a long-term and slow release of trace elements required by the body [162].…”

Section: Type I Collagen (Cgi)mentioning

confidence: 99%

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Stafin,

Śliwa,

Piątkowski

2023

IJMS

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“…The surface coating of titanium-based devices by calcium phosphates provides a suitable approach to overcome their limited bioinertness and modulate their osseointegration. Given its compositional and microstructural similarity with the bone apatite, synthetic hydroxyapatite (HA) is an extensively explored calcium phosphate representative for bone-related applications [ 19 , 20 ]. The HA coating of metallic surfaces has been validated as an efficient strategy to improve post-implantation osseointegration, stabilize bone growth around the implanted device, and accelerate bone regeneration [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Grumezescu,

Gherasim,

Gălățeanu

et al. 2024

Pharmaceutics

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The bioactive surface modification of implantable devices paves the way towards the personalized healthcare practice by providing a versatile and tunable approach that increase the patient outcome, facilitate the medical procedure, and reduce the indirect or secondary effects. The purpose of our study was to assess the performance of composite coatings based on biopolymeric spheres of poly(lactide-co-glycolide) embedded with hydroxyapatite (HA) and methotrexate (MTX). Bio-simulated tests performed for up to one week evidenced the gradual release of the antitumor drug and the biomineralization potential of PLGA/HA-MTX sphere coatings. The composite materials proved superior biocompatibility and promoted enhanced cell adhesion and proliferation with respect to human preosteoblast and osteosarcoma cell lines when compared to pristine titanium.

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Assessments of dielectric and in-vitro biological properties of composite doped hydroxyapatite

Karuppasamy,

Reger,

Sapthagirivasan

et al. 2024

J Aust Ceram Soc

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Engineered functional doped hydroxyapatite coating on titanium implants for osseointegration

Cited by 23 publications

References 219 publications

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Antitumoral-Embedded Biopolymeric Spheres for Implantable Devices

Assessments of dielectric and in-vitro biological properties of composite doped hydroxyapatite

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