Engineered microneedle systems for topical cancer therapy

Jiang, Xingyu; Xia, Wenzheng; Pan, Jiaxing; Yang, Wenfang; Zhang, Shunan; Li, Chunming; Zan, Tao; Lai, Yi; Xu, Zhiai; Yu, Haijun

doi:10.1016/j.apmt.2023.101774

Cited by 7 publications

(8 citation statements)

References 142 publications

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“…Owing to the continuous updating of relevant therapeutic methods, Zhu et al designed soluble PVP microneedles (PVP/Nb 2 C MNs) loaded with Nb 2 C nanosheets for the medical ablation of NIR-II superficial tumors by combining microneedle technology, as shown in Figure 10b. [136] The results showed that the prepared microneedles exhibit excellent puncture and drug delivery capabilities. Under the irradiation of a 1064 nm laser (power Reproduced under the terms of the CC-BY license.…”

Section: Nb 2 Cmentioning

confidence: 92%

“…designed soluble PVP microneedles (PVP/Nb 2 C MNs) loaded with Nb 2 C nanosheets for the medical ablation of NIR‐II superficial tumors by combining microneedle technology, as shown in Figure 10b. [ 136 ] The results showed that the prepared microneedles exhibit excellent puncture and drug delivery capabilities. Under the irradiation of a 1064 nm laser (power density: 1 W cm −2 ), microneedles inserted into the skin can quickly dissolve and release the loaded Nb 2 C nanosheets, and the temperature around the microneedles can reach up to 70 °C.…”

Section: Application Of 2d Mxenes In the Photothermal Treatment Of Ni...mentioning

confidence: 99%

Section: Application Of 2d Mxenes In the Photothermal Treatment Of Ni...mentioning

confidence: 99%

mentioning

confidence: 99%

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Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Li,

Wang,

et al. 2023

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The use of photothermal therapy (PTT) with the near‐infrared II region (NIR‐II: 1000–1700 nm) is expected to be a powerful cancer treatment strategy. It retains the noninvasive nature and excellent temporal and spatial controllability of the traditional PTT, and offers significant advantages in terms of tissue penetration depth, background noise, and the maximum permissible exposure standards for skin. MXenes, transition‐metal carbides, nitrides, and carbonitrides are emerging inorganic nanomaterials with natural biocompatibility, wide spectral absorption, and a high photothermal conversion efficiency. The PTT of MXenes in the NIR‐II region not only provides a valuable reference for exploring photothermal agents that respond to NIR‐II in 2D inorganic nanomaterials, but also be considered as a promising biomedical therapy. First, the synthesis methods of 2D MXenes are briefly summarized, and the laser light source, mechanism of photothermal conversion, and evaluation criteria of photothermal performance are introduced. Second, the latest progress of PTT based on 2D MXenes in NIR‐II are reviewed, including titanium carbide (Ti3C2), niobium carbide (Nb2C), and molybdenum carbide (Mo2C). Finally, the main problems in the PTT application of 2D MXenes to NIR‐II and future research directions are discussed.

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Section: Nb 2 Cmentioning

confidence: 92%

Section: Application Of 2d Mxenes In the Photothermal Treatment Of Ni...mentioning

confidence: 99%

Section: Application Of 2d Mxenes In the Photothermal Treatment Of Ni...mentioning

confidence: 99%

mentioning

confidence: 99%

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Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Li,

Wang,

et al. 2023

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“…These dosage forms are commonly used in wound care today [47,48]. They have evolved from ancient formulations, including ointments applied to the skin to modern microneedle patches [49,50]. Transdermal dosage forms have gained popularity due to several advantages over conventional topical dosage forms, including controlled drug release, the potential to prevent first-pass metabolism in the liver, long duration of action, and stable plasma profiles that ameliorate therapeutic efficacy by reducing systemic adverse effects [51,52].…”

Section: Information About Wound and Wound Carementioning

confidence: 99%

Mothers Knowledge Towards Wound Care in the Greater Bandung Area

OKTAVIANI,

ZUHROTUN,

BARKAH

2023

Int J App Pharm

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Objective: Proper wound care is essential to prevent complications and worsening of the injured patient. Everyone in the family needs to possess wound care knowledge, especially the mother, who plays a role in making decisions about health care and family health behaviors. This study aims to evaluate mothers' knowledge towards wound care in the Greater Bandung Area. Methods: This cross-sectional study involved 100 participants with varied backgrounds and had met the inclusion criteria. The study was conducted using questionnaires distributed online to the mother community living in the Greater Bandung Area, West Java, then data processing and analysis were carried out. Results: The results showed that mothers in the Greater Bandung Area had a good level of knowledge (27%), average (52%), and less (21%). In addition, plasters with wound care solutions were still the mothers' main choice in wound care. Nevertheless, there are many choices of pharmaceutical dosage forms for wound care that have been developed today to optimize the wound healing process. Conclusion: Most of the mothers already have an average level of knowledge to good. However, there are still quite a lot of mothers who have a lack of knowledge related to wound care. Therefore, educational programs must be developed to raise awareness about wound care and management, as well as knowledge about pharmaceutical dosage forms for wound care.

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Enhancing Penetration Performance and Drug Delivery of Polymeric Microneedles Using Silica Nanoparticle Coatings

Kim,

Choi,

Jeong

et al. 2024

Adv Materials Inter

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Microneedle (MN) technology offers a powerful approach for transdermal delivery enabling painless injection and facilitating self‐administration without the need for professional assistance. However, the weak mechanical strength of MNs can lead to inefficient drug delivery and serious skin irritation if the MNs fracture during administration and leave fragments under the skin. Thus, the MNs need to be mechanically robust to avoid fracture during penetration through the skin while maintaining efficient drug delivery. Herein, the polymer‐based MNs with layer‐by‐layer (LbL) films of silica (SiO2) nanoparticles (NPs) and a polycation (poly(diallyldimethylammonium chloride) (PDADMAC)) followed by hydrothermal calcination are reinforced. The mechanical strength of the MNs is significantly improved after LbL assembly and shows lower threshold pressure to penetrate skins. Moreover, their drug loading and releasing properties are significantly enhanced due to an increase in the surface area and interfacial interaction. These SiO2 nanoparticle‐containing LbL thin films have great potential for the surface modification of 3D microstructured devices such as MNs, as evidenced by their enhanced mechanical strength and drug coating efficiency that result in a promising MN drug delivery model.

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Engineered microneedle systems for topical cancer therapy

Cited by 7 publications

References 142 publications

Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Recent Advances in Photothermal Therapy at Near‐Infrared‐II Based on 2D MXenes

Mothers Knowledge Towards Wound Care in the Greater Bandung Area

Enhancing Penetration Performance and Drug Delivery of Polymeric Microneedles Using Silica Nanoparticle Coatings

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