Engineered nanoparticles for imaging and drug delivery in colorectal cancer

Pavitra, E.; Dariya, Begum; Srivani, Gowru; Kang, Sung-Min; Alam, Afroz; Sudhir, Putty‐Reddy; Kamal, Mohammad Amjad; Raju, G. Seeta Rama; Han, Young‐Kyu; Lakkakula, Bhaskar V. K. S.; Nagaraju, Ganji Purnachandra; Huh, Yun Suk

doi:10.1016/j.semcancer.2019.06.017

Cited by 78 publications

(47 citation statements)

References 137 publications

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“…NPs can be defined as particulate matter ranging from 1 to 100 nm in size with a high specific surface area and specialized surface characteristics [4].…”

Section: Nanoparticlesmentioning

confidence: 99%

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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“…NPs can be defined as particulate matter ranging from 1 to 100 nm in size with a high specific surface area and specialized surface characteristics [4].…”

Section: Nanoparticlesmentioning

confidence: 99%

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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“…These unique "polymeric compounds" can form intelligent species after modification, transporting drugs into specific areas and at the same time can be used for monitoring the state of organs attacked by cancer cells, as well as the progress of the curing process [14]. Recent advances in nanotechnology have rendered it an attractive approach for designing novel clinical solutions for CRC [14].…”

Section: Dendrimer Nanoparticles In Crcmentioning

confidence: 99%

“…Reprinted with permission from [1]. The discovery of non-biodegradable nanoparticles including micelles, nanogels, liposomes, nanoemulsions, polymeric NPs, gold NPs and magnetic NPs, as agents in nano-drug delivery and imaging at pathological sites has enhanced delivery at lower doses and increased aqueous solubility and bioavailability of the drug with reduced side effects [14]. Nevertheless, the clinical application of these NPs to CRC therapy remains limited, as can be seen in Table 1.…”

mentioning

confidence: 99%

Dendrimer nanoparticles for colorectal cancer applications

2020

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“…Chemotherapy remains a mainstay regimen for the management of CRC. In particular, the use of nanoparticles (NPs) has been widely successful for pharmaceutical delivery of active compounds ( Pavitra et al, 2019 ). This approach enables higher intratumoral drug delivery and reduced systemic toxicity than free drug dosages ( Omar et al, 2007 ; Pinto, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

Ying

Bai

Gao

et al. 2021

Front. Bioeng. Biotechnol.

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Colorectal cancer (CRC) is one of the most common and lethal human malignancies worldwide; however, the therapeutic outcomes in the clinic still are unsatisfactory due to the lack of effective and safe therapeutic regimens. Orally administrable and CRC-targetable drug delivery is an attractive approach for CRC therapy as it improves the efficacy by local drug delivery and reduces systemic toxicity. Currently, chemotherapy remains the mainstay modality for CRC therapy; however, most of chemo drugs have low water solubility and are unstable in the gastrointestinal tract (GIT), poor intestinal permeability, and are susceptible to P-glycoprotein (P-gp) efflux, resulting in limited therapeutic outcomes. Orally administrable nanoformulations hold the great potential for improving the bioavailability of poorly permeable and poorly soluble therapeutics, but there are still limitations associated with these regimes. This review focuses on the barriers for oral drug delivery and various oral therapeutic nanoparticles for the management of CRC.

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Engineered nanoparticles for imaging and drug delivery in colorectal cancer

Cited by 78 publications

References 137 publications

Lipid Based Drug Delivery System: A Review

Lipid Based Drug Delivery System: A Review

Dendrimer nanoparticles for colorectal cancer applications

Orally Administrable Therapeutic Nanoparticles for the Treatment of Colorectal Cancer

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