Engineered nanostructures to carry the biological ligands

Gopinath, Subash C. B.; Ramanathan, Santheraleka; Suk, Koh Hann; Foo, Mu Ee; Anbu, Periasamy; Uda, M. N. A.

doi:10.1051/matecconf/201815006002

Cited by 25 publications

(9 citation statements)

References 18 publications

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“…Low quantities of carbon, oxygen and calcium were also observed. The EDX data obtained for the J5 sample by FESEM were essentially in good agreement with the EDX data obtained from FETEM in terms of the elemental composition and the Si to Al ratio, which proved the formation of crystalline aluminosilicate nanocomposites from joss fly ash 28 . Table 1 shows the EDX data of the experimental samples analyzed with FETEM and FESEM.…”

Section: Resultssupporting

confidence: 78%

Aluminosilicate Nanocomposites from Incinerated Chinese Holy Joss Fly Ash: A Potential Nanocarrier for Drug Cargos

Ramanathan

Gopinath

Arshad

et al. 2020

Sci Rep

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An incredible amount of joss fly ash is produced from the burning of Chinese holy joss paper; thus, an excellent method of recycling joss fly ash waste to extract aluminosilicate nanocomposites is explored. The present research aims to introduce a novel method to recycle joss fly ash through a simple and straightforward experimental procedure involving acidic and alkaline treatments. The synthesized aluminosilicate nanocomposite was characterized to justify its structural and physiochemical characteristics. A morphological analysis was performed with field-emission transmission electron microscopy, and scanning electron microscopy revealed the size of the aluminosilicate nanocomposite to be ~25 nm, while also confirming a uniformly spherical-shaped nanostructure. The elemental composition was measured by energy dispersive spectroscopy and revealed the Si to Al ratio to be 13.24 to 7.96, showing the high purity of the extracted nanocomposite. The roughness and particle distribution were analyzed using atomic force microscopy and a zeta analysis. X-ray diffraction patterns showed a synthesis of faceted and cubic aluminosilicate crystals in the nanocomposites. The presence of silica and aluminum was further proven by X-ray photoelectron spectroscopy, and the functional groups were recognized through Fourier transform infrared spectroscopy. The thermal capacity of the nanocomposite was examined by a thermogravimetric analysis. In addition, the research suggested the promising application of aluminosilicate nanocomposites as drug carriers. The above was justified by an enzyme-linked apta-sorbent assay, which claimed that the limit of the aptasensing aluminosilicateconjugated ampicillin was twofold higher than that in the absence of the nanocomposite. The drug delivery property was further justified through an antibacterial analysis against Escherichia coli (gramnegative) and Bacillus subtilis (gram-positive). An increasing amount of fly ash is being produced at an alarming rate throughout the world, and it is not a simple subject to be neglected. More than 90 million tons of fly ash are being produced annually in India, China and the USA and ~50,000 acres of land are used for ash ponds 1. Apart from coal combustion in thermal power plants, joss paper fly ash also shows a significant contribution toward tremendous fly ash accumulation. Joss paper has been used since the time of the six dynasties, and it is widely burned by the Chinese population during their festivals and funerals as a notable tradition. An estimated 90,000 to 220,000 tons of joss paper is burned each year. Although the exact figure has not been identified, it is one of the main causes of air pollution, predominantly in China and Taiwan. Efforts toward the invention of ecofriendly burning furnaces with high-efficiency incinerators, to reduce the release of heavy metals from fly ash, are not disregarded but have never met the expected objective 2,3. Several efforts have been shown for the disposal or recycling of joss fly ash. The consumption of fly ash...

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Section: Resultssupporting

confidence: 78%

Aluminosilicate Nanocomposites from Incinerated Chinese Holy Joss Fly Ash: A Potential Nanocarrier for Drug Cargos

Ramanathan

Gopinath

Arshad

et al. 2020

Sci Rep

Self Cite

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“…Further, there is no significant difference in the antimicrobial activity against B. subtilis and E. coli. This study is well supported by and can be correlated with the previous findings which were demonstrated using graphene and silver nanoparticle conjugating the herbal extract for microbial inhibitions [2,10].…”

Section: Antimicrobial Activity Of Herbal Extract and Gnp Conjugatesupporting

confidence: 89%

“…The presence of GNP was confirmed using energy-dispersive X-ray (EDX) spectroscopy. Sample preparation for TEM was done by depositing on a copper grid, and the samples were analyzed after evaporating the liquid portion [2,10].…”

Section: Morphological Observationmentioning

confidence: 99%

“…The samples were analyzed using Shimadzu 8400 s within a spectral range of 400-4000 cm −1 . The purpose of this method was to predict the chemical functional groups of the samples [2,10].…”

Section: Fourier-transform Infrared (Ftir) Spectroscopymentioning

confidence: 99%

“…Before the existence of microbes was discovered, humans believed that plants have healing properties, reflecting the current antimicrobial characterization principles [1,2]. Formerly, humans utilized plants to treat infectious diseases, and the so-called "traditional medicines" are still being used for the treatment of various illnesses [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

Razalli¹,

Gopinath²,

Kasim³

et al. 2019

INNOCS Theranos Pharmco Sci

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Background: Herbal extracts have been traditionally used as antibacterial agents, and different strategies have been proposed to enhance their antimicrobial activities. This research aimed to assess the antimicrobial potential of Andrographis paniculata conjugated gold nanoparticle (GNP) compounds against Escherichia coli and Bacillus subtilis.Methods: Herbal extract was conjugated with GNP through electrostatic interaction, and characterization was carried out by Fourier-transmission infrared spectroscopy, screening electron microscopy, and transmission electron microscopy and supported by energy-dispersive X-ray spectroscopy. Antibacterial activity of the herbal extract and GNP conjugation was evaluated by disc diffusion assay.Results: Chemical and morphological characterizations of the GNP and herbal extract conjugate revealed intactness of the GNP. In disc diffusion assay, the inhibition zone formed by these compounds was measured for both microorganisms, and they were in the range of 0.6-0.9 cm for the herbal extract. When the herbal extract conjugated with GNP, the zone was between 0.8 and 1.1 cm.Conclusion: This study demonstrated the potentiality of GNP to carry the antibacterial compounds from the herbal extract.

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Sensitive determination of NT‐proBNP for diagnosing abdominal aortic aneurysms incidence on interdigitated electrode sensor

Qiu

Wang

Zhang

et al. 2020

Biotech and App Biochem

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Abdominal aortic aneurysm (AAA) is a vascular disease found to have progressive growth in the area of aorta. Rupturing of aorta causes excessive bleeding that leads to health‐related issues, which can be fatal sometimes. Therefore, it becomes important to make early diagnosis of AAA and its condition and start immediate treatment. Blood‐based biomarker helps to diagnose AAA and to monitor the condition after AAA surgery. N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) is a hormone produced in the heart in small quantities and increased when the heart needs to work harder. NT‐proBNP was proved to be strongly linked with AAA incidence. Moreover, quantifying the level of NT‐proBNP helps to determine the risk factors on cardiovascular system after the surgery. This work is quantifying the NT‐proBNP on interdigitated electrode sensor by using NT‐proBNP binding aptamer. The detection limit of NT‐proBNP was calculated as 1 pg/mL on a linear regression curve [y = 0.2148x + 0.8849; R² = 0.9049]. The linear range with dose‐dependent analysis was from 0.01 until 100 ng/mL. Moreover, the control experiment with complementary aptamer sequence did not show the current signal, specifying the detection of NT‐proBNP. This research benefits to identify the heart condition of patient after the removal of AAA.

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Engineered nanostructures to carry the biological ligands

Cited by 25 publications

References 18 publications

Aluminosilicate Nanocomposites from Incinerated Chinese Holy Joss Fly Ash: A Potential Nanocarrier for Drug Cargos

Aluminosilicate Nanocomposites from Incinerated Chinese Holy Joss Fly Ash: A Potential Nanocarrier for Drug Cargos

Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

Sensitive determination of NT‐proBNP for diagnosing abdominal aortic aneurysms incidence on interdigitated electrode sensor

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