Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

Yang, Yaoyao; Chen, Wei; Wang, Menglong; Shen, Jiachen; Zheng, Tao; Qin, Yanguo; Yu, Deng‐Guang

doi:10.3390/polym15102237

Cited by 21 publications

(14 citation statements)

References 95 publications

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“…In contrast, the first-order release kinetics of Run 3 and Run 18 (large-diameter fibers) were characterized by R 2 values of 0.9741 and 0.9558, respectively. The sustained release pattern that minimizes explosive release and attains a constant drug concentration within the therapeutic range is the zero-order release pattern [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

“…A constant release rate is maintained as the molecules are continuously replenished from within the matrix as they diffuse out of the fibers [ 73 ]. Additionally, the relatively slow dissolution rate of shellac, influenced by water absorption and expansion, further contributes to the formation of sustained release profiles, emphasizing the suitability of these fibers for controlled drug release applications [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

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Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

Aung,

Krongrawa,

Limmatvapirat

et al. 2024

Polymers

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Single-fluid electrospinning creates nanofibers from molten polymer solutions with active ingredients. This study utilized a combination of a fractional factorial design and a Box–Behnken design to examine crucial factors among a multitude of parameters and to optimize the electrospinning conditions that impact fiber mats’ morphology and the entrapment efficiency of Senna alata leaf extract. The findings indicated that the shellac content had the greatest impact on both fiber diameter and bead formation. The optimum electrospinning conditions were identified as a voltage of 24 kV, a solution feed rate of 0.8 mL/h, and a shellac–extract ratio of 38.5:3.8. These conditions produced nanosized fibers with a diameter of 306 nm, a low bead-to-fiber ratio of 0.29, and an extract entrapment efficiency of 96% within the fibers. The biphasic profile of the optimized nanofibers was confirmed with an in vitro release study. This profile consisted of an initial burst release of 88% within the first hour, which was succeeded by a sustained release pattern surpassing 90% for the next 12 h, as predicted with zero-order release kinetics. The optimized nanofibers demonstrated antimicrobial efficacy against diverse pathogens, suggesting promising applications in wound dressings and protective textiles.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

Aung,

Krongrawa,

Limmatvapirat

et al. 2024

Polymers

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“…Yang's group prepared innovative two-chamber core-shell fibers for colon-targeted drug delivery (Yang et al, 2023). The pH-sensitive shellac was used as the shell layer, whereas drugs and polyethylene oxide were used as the core layer.…”

Section: Colonmentioning

confidence: 99%

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Liu,

Chen,

Lin

et al. 2024

WIREs Nanomed Nanobiotechnol

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Core–shell structure is a concentric circle structure found in nature. The rapid development of electrospinning technology provides more approaches for the production of core–shell nanofibers. The nanoscale effects and expansive specific surface area of core–shell nanofibers can facilitate the dissolution of drugs. By employing ingenious structural designs and judicious polymer selection, specialized nanofiber drug delivery systems can be prepared to achieve controlled drug release. The synergistic combination of core–shell structure and materials exhibits a strong strategy for enhancing the drug utilization efficiency and customizing the release profile of drugs. Consequently, multi‐chamber core–shell nanofibers hold great promise for highly efficient disease treatment. However, little attention concentration is focused on the effect of multi‐chamber core–shell nanofibers on controlled release of drugs. In this review, we introduced different fabrication techniques for multi‐chamber core–shell nanostructures, including advanced electrospinning technologies and surface functionalization. Subsequently, we reviewed the different controlled drug release behaviors of multi‐chamber core–shell nanofibers and their potential needs for disease treatment. The comprehensive elucidation of controlled release behaviors based on electrospun multi‐chamber core–shell nanostructures could inspire the exploration of novel controlled delivery systems. Furthermore, once these fibers with customizable drug release profiles move toward industrial mass production, they will potentially promote the development of pharmacy and the treatment of various diseases.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…Additionally, targeted release and drug combinations represent more specialized release modes. Figure 3 provides an overview of the release curves corresponding to these different release modes in drug-loaded electrospun nanofibers [ 9 , 63 , 64 , 65 ]. Table 1 summarizes the typical drug-release methods and indications for electrospun drug-loaded nanofibers [ 9 , 14 , 25 , 58 , 61 , 64 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ].…”

Section: Drug Release Modes Of Drug-loaded Nanofibersmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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Engineered Shellac Beads-on-the-String Fibers Using Triaxial Electrospinning for Improved Colon-Targeted Drug Delivery

Cited by 21 publications

References 95 publications

Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

Fabrication and Optimization of Electrospun Shellac Fibers Loaded with Senna alata Leaf Extract

Electrospun multi‐chamber core–shell nanofibers and their controlled release behaviors: A review

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

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