Engineered UIO-66 metal-organic framework for delivery of curcumin against breast cancer cells: An in vitro evaluation

Bazzazan, Saba; Moeinabadi-Bidgoli, Kasra; Lalami, Zahra Asghari; Bazzazan, Saina; Mehrarya, Mehrnoush; Yeganeh, Faten Eshrati; Hejabi, Faranak; Akbarzadeh, Iman; Noorbazargan, Hassan; Jahanbakhshi, Mehdi; Mostafavi, Ebrahim

doi:10.1016/j.jddst.2022.104009

Cited by 32 publications

(15 citation statements)

References 90 publications

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“…12,13,14,15 The combination of medicine and nanotechnology has modified multifunctional nanocarriers that can be loaded with different drugs. [15][16][17][18] Nanoparticle-based DDSs, such as liposomes, nanotubes, [19][20][21] metallic nanoparticles, 22,23 metal-organic frameworks, 24,25 mesoporous silica nanoparticles, 26 are promising carriers for targeted delivery due to their high surface area to mass ratio and high interaction which lead them to carry drug molecules efficiently rather than free drug molecules in solution. Moreover, these particles transfer their loaded active drug into cancer cells by selectively using tumors' peculiar stimuli.…”

Section: Introductionmentioning

confidence: 99%

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Ahmadi¹,

Seraj²,

Chiani³

et al. 2022

IJN

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Introduction Breast cancer is among the most prevalent mortal cancers in women worldwide. In the present study, an optimum formulation of letrozole, letrozole-loaded niosome, and empty niosome was developed, and the anticancer effect was assessed in in vitro MCF-7, MCF10A and MDA-MB-231 breast cancer cell lines. Materials and Methods Various niosomal formulations of letrozole were fabricated through thin-film hydration method and characterized in terms of size, polydispersity index (PDI), morphology, entrapment efficiency (EE%), release kinetics, and stability. Optimized niosomal formulation of letrozole was achieved by response surface methodology (RSM). Antiproliferative activity and the mechanism were assessed by MTT assay, quantitative real-time PCR, and flow cytometry. Furthermore, cellular uptake of optimum formulation was evaluated by confocal electron microscopy. Results The formulated letrozole had a spherical shape and showed a slow-release profile of the drug after 72 h. The size, PDI, and eEE% of nanoparticles showed higher stability at 4°C compared with 25°C. The drug release from niosomes was in accordance with Korsmeyer–Peppa’s kinetic model. Confocal microscopy revealed the localization of drug-loaded niosomes in the cancer cells. MTT assay revealed that all samples exhibited dose-dependent cytotoxicity against breast cancer cells. The IC 50 of mixed formulation of letrozole with letrozole-loaded niosome (L + L 3 ) is the lowest value among all prepared formulations. L+L 3 influenced the gene expression in the tested breast cancer cell lines by down-regulating the expression of Bcl 2 gene while up-regulating the expression of p53 and Bax genes. The flow cytometry results revealed that L + L 3 enhanced the apoptosis rate in both MCF-7 and MDA-MB-231 cell lines compared with the letrozole (L), letrozole-loaded niosome (L 3 ), and control sample. Conclusion Results indicated that niosomes could be a promising drug carrier for the delivery of letrozole to breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Ahmadi¹,

Seraj²,

Chiani³

et al. 2022

IJN

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“…MOFs have proven to be a highly promising platform for drug delivery due to their unique properties, such as the ability to precisely control their structure, and pore dimensions, as well as their potential for straightforward surface functionalization, high drug loading capacities, and controlled release of therapeutics in biological environments [19][20][21][22][23][24][25]. These features, along with their potential for synergistic/dual drug loading/ releasing and protection/stabilization of biomolecular therapeutics, make MOFs a versatile and valuable tool in the field of drug delivery [26][27][28][29][30]. One of the main obstacles in utilizing MOFs for drug delivery is the limited knowledge of their understanding of their biocompatibility with biological systems [31].…”

Section:  Introductionmentioning

confidence: 99%

Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks

Silva

Munasinghe

et al. 2023

Mater. Res. Express

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In this study, we present the investigation of the curcumin loading and release properties of four different Metal-Organic Frameworks (MOFs) with varying metal centres and organic ligands. Through our research, we have identified HKUST-1 and MIL-100, highly porous copper and iron-containing MOFs, that exhibit specific interactions with curcumin, leading to high encapsulation efficiencies (55%-75%) even at low concentrations as 6ppm. The binding modes of curcumin onto MOFs have been investigated using a combined experimental and computational approach. Furthermore, our drug-releasing studies have revealed slow and prolonged release for over two days, which further indicates the specific interactions of curcumin with HKUST-1 and MIL-100. To the best of our knowledge, this is the first comparative study that investigates the drug delivery properties of curcumin using Copper, Ferrous, and Zinc MOFs. Our findings pave the way for the development of stable, highly interactive MOFs as drug carriers for curcumin, which has the potential to overcome its poor aqueous solubility and rapid metabolism, and enhance its pharmacological activities in medicine.

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“…15–20 The wide range of materials synthesized so far is of interest for a number of applications such as gas separation and storage, 21–24 catalysis, 25–27 liquid-phase separation 28,29 and bio-applications. 30,31…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19][20] The wide range of materials synthesized so far is of interest for a number of applications such as gas separation and storage, [21][22][23][24] catalysis, [25][26][27] liquid-phase separation 28,29 and bio-applications. 30,31 Compounds demonstrating high structural stability are particularly important, because a number of reported MOF materials are very unstable. 32 Particular attention has been drawn to zirconium MOFs exhibiting the highest structural robustness.…”

Section: Introductionmentioning

confidence: 99%

UiO-66 framework with an encapsulated spin probe: synthesis and exceptional sensitivity to mechanical pressure

Poryvaev

Ларионов

Albrekht

et al. 2023

Phys. Chem. Chem. Phys.

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Engineered UIO-66 metal-organic framework for delivery of curcumin against breast cancer cells: An in vitro evaluation

Cited by 32 publications

References 90 publications

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks

UiO-66 framework with an encapsulated spin probe: synthesis and exceptional sensitivity to mechanical pressure

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