Engineering advanced nanomedicines against central nervous system diseases

Shi, Shuyu; Ren, Hongze; Xie, Yujie; Yu, Meihua; Chen, Yu; Yang, Liqun

doi:10.1016/j.mattod.2023.08.005

Materials Today

2023

DOI: 10.1016/j.mattod.2023.08.005

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Engineering advanced nanomedicines against central nervous system diseases

Shuyu Shi,

Hongze Ren,

Yujie Xie

et al.

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Cited by 6 publications

(1 citation statement)

References 276 publications

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“…The size of these nanomaterials is adapted according to the particles to be transported, having a diameter of approximately less than 200 nm. Additionally, other aspects are related to these systems, such as surface charge, topology, and shape [86,87].…”

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confidence: 99%

The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases

Vital Júnior,

da Silva,

Monteiro

et al. 2024

Pharmaceuticals

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This review article covers the therapeutic potential of the plants Harpagophytum procumbens and Turnera subulata in the treatment of neurodegenerative diseases. Despite the recognition of their beneficial properties, there is notable shortage of specific clinical and in vitro studies on these species regarding neurodegenerative diseases. Compounds such as harpagosides and vite-xin-2-O-rhamnoside, found in Harpagophytum procumbens and Turnera subulata, respectively, as well as other antioxidants and anti-inflammatory agents, are associated with mechanisms of action that involve reducing oxidative stress and modulating the inflammatory response, indicating their therapeutic potential in these pathologies. Additionally, the use of nutraceuticals derived from medicinal plants has emerged as a promising approach, offering natural therapeutic alternatives. However, the pressing need for studies focusing on the pharmacokinetics, safety, and pharmacological interactions of these extracts for the treatment of neurodegenerative diseases is emphasized. This review also evaluated advances in nutraceutical delivery systems, highlighting technological innovations that can optimize the precise delivery of these compounds to patients. Such findings highlight the gaps in the study of these plants for the treatment of neurodegenerative diseases and, at the same time, the potential for opening new perspectives in the treatment of neurodegenerative diseases, providing expectations for innovative solutions in this critical domain of medicine.

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mentioning

confidence: 99%

The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases

Vital Júnior,

da Silva,

Monteiro

et al. 2024

Pharmaceuticals

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Synergistic Gold Nanorod‐based Chemo‐Photothermal Therapy: A Promising Nanoparticle Approach for Refractory Multidrug‐Resistant Cancer

Alqahtani,

Alshangiti,

Aldaleeli

et al. 2024

ChemBioEng Reviews

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Multidrug resistance (MDR) remains a formidable challenge in cancer treatment, necessitating innovative strategies to enhance therapeutic outcomes. This review explores the potential of a synergistic gold nanorod (GNR) therapy (SGNRT) utilizing GNRs as multifunctional platforms for co‐delivering chemotherapy and thermal therapies. The rational design of SGNRT systems enables targeted payload delivery, circumvention of Adenosine triphosphate (ATP)‐binding cassette drug efflux transporters, and hyperthermia‐induced chemo sensitization. In vitro studies demonstrate the synergistic impact of SGNRT in overcoming MDR, emphasizing its potential for enhanced antitumor efficacy. However, further in vivo investigations are essential to assess the clinical viability of this nanoparticle (NP)‐directed approach against advanced multidrug‐resistant malignancies. The integration of SGNRT holds promise for advancing precision cancer therapies and addressing the intricate challenges of drug resistance in clinical settings.

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Progress in the treatment of Alzheimer's disease based on nanosized traditional Chinese medicines

Song,

Zhang,

et al. 2025

J. Mater. Chem. B

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Engineering advanced nanomedicines against central nervous system diseases

Cited by 6 publications

References 276 publications

The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases

The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases

Synergistic Gold Nanorod‐based Chemo‐Photothermal Therapy: A Promising Nanoparticle Approach for Refractory Multidrug‐Resistant Cancer

Progress in the treatment of Alzheimer's disease based on nanosized traditional Chinese medicines

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