Engineering approaches for innate immune-mediated tumor microenvironment remodeling

Kane, G.I.; Lusi, C.F.; Brassil, M.L.; Atukorale, P.U.

doi:10.1016/j.iotech.2023.100406

Immuno-Oncology and Technology

2024

DOI: 10.1016/j.iotech.2023.100406

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Engineering approaches for innate immune-mediated tumor microenvironment remodeling

G.I. Kane,

C.F. Lusi,

M.L. Brassil

et al.

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2024

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References 131 publications

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YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape

Xiong,

He,

Chai

et al. 2024

Cell Death Dis

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Lactate is a major metabolic product of tumor cells in microenvironment. Increasing evidence has indicated that lactate accumulation could alter the immune response in human cancers, including cervical cancer. However, the function and significance of N6-methyladenosine (m6A) reader YTHDF1 in cervical cancer cells’ lactate metabolism and immunotherapy remain obscure. Results illustrated that YTHDF1 predicted unfavorable clinical outcomes of cervical cancer, which was negatively correlated with CD8+ T cell infiltration. In the co-culture of tumor cells with CD8+ T cells, YTHDF1 overexpression promoted the lactate accumulation and attenuated the cytotoxic CD8+ T cell’s killing effect. Correspondingly, YTHDF1 knockdown exerted the opposite effects. Mechanistically, YTHDF1 targeted the m6A site on SLC16A1 gene (MCT1) to determine its fate. YTHDF1 upregulated MCT1 expression by enhancing MCT1 stability mediated by m6A-modified manner. Collectively, our results revealed an oncogenic role played by YTHDF1 in cervical cancer through m6A/MCT1-dependent manner. In conclusion, these findings unveil the immune escape-promoting effect of YTHDF1 in cervical cancer by boosting the lactate accumulation, which might illuminate a novel target for more precise immunotherapy.

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YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape

Xiong,

He,

Chai

et al. 2024

Cell Death Dis

View full text Add to dashboard Cite

show abstract

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Engineering approaches for innate immune-mediated tumor microenvironment remodeling

Cited by 1 publication

References 131 publications

YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape

YTHDF1 boosts the lactate accumulation to potentiate cervical cancer cells immune escape

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