Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

Fitzpatrick, Daniel E.; Ley, Steven V.

doi:10.1039/c6re00160b

Cited by 54 publications

(41 citation statements)

References 23 publications

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“…[11] The system was further expanded by Fitzpatrick and Ley who used it to control continuous extraction in am ulti-step synthetic workflow. [12] Their design used an inexpensive web camera to detect the position of the green colored float and sent asignal to the Raspberry Pi SBC,which further sent commands to an Arduino MCB controlling asmall peristaltic pump.…”

mentioning

confidence: 99%

Prototyping Instruments for the Chemical Laboratory Using Inexpensive Electronic Modules

Urban

2018

Angew Chem Int Ed

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Open-source electronics and programming can augment chemical and biomedical research. Currently, chemists can choose from a broad range of low-cost universal electronic modules (microcontroller boards and single-board computers) and use them to assemble working prototypes of scientific tools to address specific experimental problems and to support daily research work. The learning time can be as short as a few hours, and the required budget is often as low as 50 USD. Prototyping instruments using low-cost electronic modules gives chemists enormous flexibility to design and construct customized instrumentation, which can reduce the delays caused by limited access to high-end commercial platforms.

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confidence: 99%

Prototyping Instruments for the Chemical Laboratory Using Inexpensive Electronic Modules

Urban

2018

Angew Chem Int Ed

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“…[39] Flow synthesizers can also have limitations,such as clogging or insufficient mixing of suspensions. [40][41][42][43]…”

Section: Methodsmentioning

confidence: 99%

“…This work demonstrated that a combination of flow and batch conditions can be exceptionally effective to optimize time and yield. [40] Other groups have also recently emphasized the advantages of combining batch and continuous flow synthesizers. [41–43] …”

Section: One Machine – One Small Moleculementioning

confidence: 99%

“…This work demonstrated that ac ombination of flow and batch conditions can be exceptionally effective for optimizing time and yield. [40] Other groups have also recently emphasized the advantages of combining batch and continuous flow synthesizers. [41][42][43] Leveraging all of these advantages,i ti sn ow increasingly commonplace for pharmaceuticals and other specific small molecules known to have useful functions to be manufactured using at least partially automated customized synthesis routes.…”

Section: Reproducibilitymentioning

confidence: 99%

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The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

2018

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The eighteenth and nineteenth centuries marked a sweeping transition from manual to automated manufacturing on the macroscopic scale. This enabled an unmatched period of human innovation that helped drive the Industrial Revolution. The impact on society was transformative, ultimately yielding substantial improvements in living conditions and lifespan in many parts of the world. During the same time period, the first manual syntheses of organic molecules was achieved. Now, two centuries later, we are poised for an analogous transition from highly customized crafting of specific molecular targets by hand to the increasingly general and automated assembly of many different types of molecules with the push of a button. Automation of customized small molecule synthesis pathways is already enabling safer, more reproducible, and readily scalable production of specific targets, and general machines now exist for the synthesis of a wide range of different peptides, oligonucleotides, and oligosaccharides. Creating general machines that are similarly capable of making many different types of small molecules on-demand, akin to that which has been achieved on the macroscopic scale with 3D printers, has proven to be substantially more challenging. Yet important progress is being made toward this potentially transformative objective with two complementary approaches: (1) automation of customized synthesis routes to different targets via machines that enable use of many different reactions and starting materials, and (2) automation of generalized platforms that make many different targets using common coupling chemistry and building blocks. Continued progress in these exciting directions has the potential to shift the bottleneck in molecular innovation from synthesis to imagination, and thereby help drive a new industrial revolution on the molecular scale.

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“…In dieser Arbeit konnte gezeigt werden, dass die Kombination kontinuierlicher und diskontinuierlicher Bedingungen ein effektiver Weg zur Optimierung der Geschwindigkeit und Ausbeute sein kann. [40] Auch andere Gruppen konnten in letzter Zeit die Vorteile entsprechender kombinierter Synthesemaschinen zeigen. [41][42][43] Viele organische Verbindungen lassen sich so zumindest teilweise automatisch über angepasste Routen synthetisieren.…”

Section: Reproduzierbarkeitunclassified

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen

Trobe

Burke

2018

Angewandte Chemie

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Derzeitkündigt sichein Wandel von der manuellen Synthese spezifischer Moleküle,die über individuell angepasste Routen verläuft, hin zu automatisch zusammenfügten Verbindungen unterschiedlichster Klassen mit nur einem Knopfdruckan. Die Entwicklung einer Maschine fürdie Herstellung unterschiedlichsterorganischer Moleküle je nachBedarf ist eine komplexe Aufgabe,e ss ind aber bereits bedeutende Fortschritte auf Basis von zwei komplementären Ansätzen zu verzeichnen:1 )Automatisierung individueller Routen fürdie Synthese diverser Verbindungen, wobei viele unterschiedliche Reaktionstypen und spezifische Reagentien genutzt werden kçnnen, und 2) Automatisierung einer generellen Plattform, die die Herstellung unterschiedlicher Verbindungen ausgehend von diversen Bausteinen, die mit derselben Kupplungsreaktion verknüpft werden, ermçglicht. Fortschritte in diesen Bereichen bieten die Mçglichkeit, Synthese-Engpässe zu vermeiden und den Fokus molekularer Innovation auf die Entwicklung neuer Methoden zu lenken und so eine "molekulare industrielle Revolution" zu beschleunigen.

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Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

Abstract: Synthesis chemistry need not be limited to either only batch or only flow; rather, in the future we expect that it will consist of an amalgamation of the best and most appropriate methods.

Cited by 54 publications

References 23 publications

Prototyping Instruments for the Chemical Laboratory Using Inexpensive Electronic Modules

Prototyping Instruments for the Chemical Laboratory Using Inexpensive Electronic Modules

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen

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