Engineering goat milk-derived extracellular vesicles for multiple bioimaging-guided and photothermal-enhanced therapy of colon cancer

Abstract

Synthesis, application, and analysis of a GMV-based nanoprobe.

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

“…EVs can also take advantage of external stimuli to improve their effectiveness. Modified EVs derived from goat milk turned out to be a great platform for photothermal enhanced therapy (PTT) for colon cancer [ 223 , 224 ]. Similarly, EVs derived from macrophages or cancer cells were loaded with photosensitizer zinc phthalocyanine (ZnPc), which increases the effectiveness of phototherapy in these treatment strategies with the promotion of immunological memory [ 225 ].…”

Mn(ii)–hemoporfin-based metal–organic frameworks as a theranostic nanoplatform for MRI-guided sonodynamic therapy

“…Among emerging therapies for cancer treatment, sonodynamic therapy (SDT) has drawn much attention, which utilized ultrasound to activate sonosensitizers retained in tumor areas, effectively killing cancer cells with minor side effects. [8][9][10] Sonosensitizers such as organic molecules (e.g., porphyrin, rose bengal, or curcumin derivatives), [11][12][13] inorganic nanomaterials (e.g., noble metal nanoparticles, transition metal oxides, or semiconductors), [14][15][16] and organic-inorganic hybrid nanomaterials (e.g., metalloporphyrin complex, mesoporous nanoparticles, or metal-organic frameworks) [17][18][19] have been developed for SDT. However, the therapeutic efficacy of SDT cannot meet clinical needs due to the heterogeneity of tumors between patients, 20 rendering it unsuitable for all individuals.…”

NIR-II imaging-guided photothermal cancer therapy combined with enhanced immunogenic death

“…16,17 However, it is often difficult to achieve satisfactory therapeutic effects with a single photothermal therapy. First, it is because the limitations of photothermal therapy itself make it difficult to effectively inhibit and eliminate distal tumors and metastases, 18,19 † Electronic supplementary information (ESI) available: Calculation of the photothermal conversion efficiency. Solution color changes during the synthesis process of GdOF@PDA NPs.…”

“…16,17 However, it is often difficult to achieve satisfactory therapeutic effects with a single photothermal therapy. First, it is because the limitations of photothermal therapy itself make it difficult to effectively inhibit and eliminate distal tumors and metastases, 18,19 and second, it is because the presence of a tumor immunosuppressive microenvironment inhibits the specific anti-tumor immune response induced by photothermal therapy. 20,21 Therefore, overcoming these obstacles is of great importance for the elimination and suppression of tumors.…”