Engineering Gold Nanotubes with Controlled Length and Near‐Infrared Absorption for Theranostic Applications

S, Ye; Marston, Gemma; McLaughlan, James R.; Sigle, Daniel O.; Ingram, Nicola; Freear, Steven; Baumberg, Jeremy J.; Bushby, Richard J.; Markham, Alexander F.; Critchley, Kevin; Coletta, P. Louise; Evans, Stephen D.

doi:10.1002/adfm.201404358

Cited by 81 publications

(84 citation statements)

References 56 publications

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“…Thus, Xia group has widely studied how Ag nanocubes synthesized by using a polyol process and then oxidized by an aqueous HAuCl 4 solution generate uniform Au nanoboxes or nanocages [64,[96][97][98][99]. Similarly, Ag nanowires have been widely exploited as templates for the preparation of hollow nanotubes via the GRR [86,97,[100][101][102][103][104]. Other structures commonly obtained through the GRR between HAuCl 4 and the corresponding Ag template include nanorings [105,106], nanoframes [107][108][109], and nanorattles [110][111][112][113][114].…”

Section: Synthesis Of Hollow Nanostructuresmentioning

confidence: 99%

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

et al. 2016

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Metallic nanostructures have received great attention due to their ability to generate surface plasmon resonances, which are collective oscillations of conduction electrons of a material excited by an electromagnetic wave. Plasmonic metal nanostructures are able to localize and manipulate the light at the nanoscale and, therefore, are attractive building blocks for various emerging applications. In particular, hollow nanostructures are promising plasmonic materials as cavities are known to have better plasmonic properties than their solid counterparts thanks to the plasmon hybridization mechanism. The hybridization of the plasmons results in the enhancement of the plasmon fields along with more homogeneous distribution as well as the reduction of localized surface plasmon resonance (LSPR) quenching due to absorption. In this review, we summarize the efforts on the synthesis of hollow metal nanostructures with an emphasis on the galvanic replacement reaction. In the second part of this review, we discuss the advancements on the characterization of plasmonic properties of hollow nanostructures, covering the single nanoparticle experiments, nanoscale characterization via electron energy-loss spectroscopy and modeling and simulation studies. Examples of the applications, i.e. sensing, surface enhanced Raman spectroscopy, photothermal ablation therapy of cancer, drug delivery or catalysis among others, where hollow nanostructures perform better than their solid counterparts, are also evaluated.

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Section: Synthesis Of Hollow Nanostructuresmentioning

confidence: 99%

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

et al. 2016

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“…Since the first report of Au nanocages synthesized from Ag nanocubes, various hollow Au nanoshell structures have been prepared using Ag nanospheres [144][145][146][147][148][149][150][151][152][153][154][155], Ag nanorods [156][157][158][159], Ag nanowires [160], and even Ag islands on two-dimensional surfaces as templates [161].…”

Section: Hollow Nanoshellsmentioning

confidence: 99%

Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

Shin¹,

Kang²,

Jang³

2018

Preprint

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Owing to their unique physicochemical properties, nanoparticles are used in a variety of ways in the field of cancer treatment, including imaging, drug delivery, and photothermal and photodynamic therapies. The fascinating properties of nanoparticles are determined by their size, morphology, and constituent elements, and various synthetic methods and post-synthetic techniques have been applied to control these factors. Herein, we present examples of shape and composition control through galvanic replacement, a technique that exploits redox potential differences between elements to induce spontaneous ion-exchange and highlight its specific contributions to cancer treatment applications. The present article identifies the recent advances in nanoparticle formation techniques and discusses the future outlook of the field.

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“…The PEG modified gold nanoprims were synthesized according to our previous report [46]. First, we mixed 10 ml of 2 mM chloroauric acid and 12 mL of 0.5 mM sodium thiosulfate (reducing regent) attired gently for 9 mins at room temperature.…”

Section: Preparation and Characterization Of Pegylated Aunprsmentioning

confidence: 99%

“…The gold nanoprisms (AuNPrs) were synthesized according to previous report [46], a straightforward method without any toxic reagents used, such as cetyltrimethylammonium bromide (CTAB). 10 mL of 2 mM chloroauric acid (HAuCl4) and 12 mL of freshly prepared 0.5 mM sodium thiosulfate (Na2S2O3) were mixed, and stirred at 30 °C for 9 mins.…”

Section: Preparation and Characterization Of Pegylated Aunprsmentioning

confidence: 99%

Human CIK Cells Loaded with Gold Nanoprisms as Theranostic Platform for Targeted Photoacoustic Imaging and Enhanced Immuno-Photothermal Combined Therapy

Zhang¹,

Xia²,

Yang³

et al. 2016

Nano BioMed ENG

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How to enhance the therapeutic efficacy of human cytokine induced killers cell (CIK) has become a great challenge. Herein, we report for the first time that human CIK cells loaded with gold nanoprisms were successfully used for targeted photoacoustic imaging, enhanced immunotherapy and photothermal therapy of gastric cancer in vivo. Gold nanoprisms were synthesized and modified with PEG; human CIK cells were prepared and incubated with PEGylated gold nanoprisms (Au GNPrs), and then the effects of human CIK cells labeled with Au NPrs on gastric cancer MGC 803 cells were evaluated and further used for targeted photoacoustic imaging, immunotherapy and photothermal therapy of gastric cancer in vivo in mice models. Results showed that PEGylated Au NPrs could be uptaken high-efficiently by human CIK cells, resultant human CIK cells labeled with AuNPrs could inhibit the growth of gastric cancer MGC 803 cells actively by induced apoptosis and G1 phase arrest, and actively target and accumulate the tumor sites in gastric cancer-bearing nude mice. Enhanced synergistic therapeutic efficacy was demonstrated with the maximal inhibition of tumor through a combination of CIK cells-based immunotherapy for three days and then a continuous gold nanoprisms-based photothermal therapy. In conclusion, human CIK cells labeled with PEGylated Au NPrs can target gastric cancer cells in vivo, enhance immunotherapy and photothermal therapy efficacy, and have a great potential in applications such as targeted imaging, immunotherapy and photothermal therapy of gastric cancer in the near future.

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Engineering Gold Nanotubes with Controlled Length and Near‐Infrared Absorption for Theranostic Applications

Abstract: Important aspects in engineering gold nanoparticles for theranostic applications include the control of size, optical properties, cytotoxicity, biodistribution and clearance. In this study,

Cited by 81 publications

References 56 publications

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

Hollow metal nanostructures for enhanced plasmonics: synthesis, local plasmonic properties and applications

Recent Advances in Nanoparticle Shape and Composition Regulation Based on Galvanic Replacement for Cancer Treatment

Human CIK Cells Loaded with Gold Nanoprisms as Theranostic Platform for Targeted Photoacoustic Imaging and Enhanced Immuno-Photothermal Combined Therapy

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