Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Zhang, Miaomiao; Ju, Huixiang; Zhang, Li; Sun, Mingzhong; Zhao, Zhengping; Dai, Zhenyu; Zhang, Lirong; Gong, Aihua; Wu, Chaoyang; Du, F.

doi:10.2147/ijn.s82778

Cited by 36 publications

(6 citation statements)

References 31 publications

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“…A broad reflection observed around 25°, which corresponds to the graphitic carbon(002) plane, is due to the small size of the C-dots [41]. These diffraction peaks match well with the characteristic peaks of graphene oxide [42–44], and they are also in agreement with the HR-TEM lattice distances measured.…”

Section: Resultssupporting

confidence: 74%

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

Vasimalai

Vilas-Boas

Gallo

et al. 2018

Beilstein J. Nanotechnol.

165

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Carbon dots have demonstrated great potential as luminescent nanoparticles in bioapplications. Although such nanoparticles appear to exhibit low toxicity compared to other metal luminescent nanomaterials, today we know that the toxicity of carbon dots (C-dots) strongly depends on the protocol of fabrication. In this work, aqueous fluorescent C-dots have been synthesized from cinnamon, red chilli, turmeric and black pepper, by a one-pot green hydrothermal method. The synthesized C-dots were firstly characterized by means of UV–vis, fluorescence, Fourier transform infrared and Raman spectroscopy, dynamic light scattering and transmission electron microscopy. The optical performance showed an outstanding ability for imaging purposes, with quantum yields up to 43.6%. Thus, the cytotoxicity of the above mentioned spice-derived C-dots was evaluated in vitro in human glioblastoma cells (LN-229 cancer cell line) and in human kidney cells (HK-2 non-cancerous cell line). Bioimaging and viability studies were performed with different C-dot concentrations from 0.1 to 2 mg·mL−1, exhibiting a higher uptake of C-dots in the cancer cultures compared to the non-cancerous cells. Results showed that the spice-derived C-dots inhibited cell viability dose-dependently after a 24 h incubation period, displaying a higher toxicity in LN-229, than in HK-2 cells. As a control, C-dots synthesized from citric acid did not show any significant toxicity in either cancerous or non-cancerous cells, implying that the tumour cell growth inhibition properties observed in the spice-derived C-dots can be attributed to the starting material employed for their fabrication. These results evidence that functional groups in the surface of the C-dots might be responsible for the selective cytotoxicity, as suggested by the presence of piperine in the surface of black pepper C-dots analysed by ESI-QTOF-MS.

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Section: Resultssupporting

confidence: 74%

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

Vasimalai

Vilas-Boas

Gallo

et al. 2018

Beilstein J. Nanotechnol.

165

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“…3 B, there are four major diffraction peaks at 24.4°, 30.3°, 35.23°, and 43.2°. One of these peaks at 24.4° may be ascribed to the produced inorganic carbonaceous structure, which is similar to the reported carbon quantum dots and graphite characteristic peaks [ 27 – 29 ]. Compared to the ordered crystal structure of graphite (002 planes, 2 θ = 26.5°), the diffraction peak of Ce-doped CNPs around 24.4° with a lower shift becomes weak, which may be attributed to highly disorder carbon and increase in the sp 2 (C–C) layer spacing in the carbonization process [ 30 ].…”

Section: Resultssupporting

confidence: 84%

Biomineralization-Inspired Synthesis of Cerium-Doped Carbonaceous Nanoparticles for Highly Hydroxyl Radical Scavenging Activity

et al. 2018

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Cerium oxide nanoparticles recently have received extensive attention in biomedical applications due to their excellent anti-oxidation performance. In this study, a simple, mild, and green approach was developed to synthesize cerium-doped carbonaceous nanoparticles (Ce-doped CNPs) using bio-mineralization of bull serum albumin (BSA) as precursor. The resultant Ce-doped CNPs exhibited uniform and ultrasmall morphology with an average size of 14.7 nm. XPS and FTIR results revealed the presence of hydrophilic group on the surface of Ce-doped CNPs, which resulted in excellent dispersity in water. The CCK-8 assay demonstrated that Ce-doped CNPs possessed favorable biocompatibility and negligible cytotoxicity. Using H2O2-induced reactive oxygen species (ROS) as model, Ce-doped CNPs showed highly hydroxyl radical scavenging capability. Furthermore, flow cytometry and live-dead staining results indicated that Ce-doped CNPs protected cells from H2O2-induced damage in a dose-dependent effect, which provided a direct evidence for anti-oxidative performance. These findings suggest that Ce-doped CNPs as novel ROS scavengers may provide a potential therapeutic prospect in treating diseases associated with oxidative stress.

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“…Besides the MRI/FI dual-modal imaging, computed tomography (CT) is another common bioimaging technique in the clinical diagnosis. Zhang et al synthesized Iodine (I) doped CDs (I-CDs) from iodixanol and glycine [83] or citric acid [84] by hydrothermal route at 180 • C for 3 h. The aqueous I-CDs solution exhibited excitation-dependent and stable emissions with a maximum at 475 nm. I-doped CDs further displayed superior X-ray attenuation properties and excellent biocompatibility in vitro.…”

Section: Multimodal Imagingmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging

Cited by 36 publications

References 31 publications

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

Biomineralization-Inspired Synthesis of Cerium-Doped Carbonaceous Nanoparticles for Highly Hydroxyl Radical Scavenging Activity

Recent advance of carbon dots in bio-related applications

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