Engineering Magnetic Nanoparticles for Thermo-Ablation and Drug Delivery in Neurological Cancers

Jacob, Ayden; Chakravarthy, Krishnan

doi:10.7759/cureus.170

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Usage of superparamagnetic magnetic beads (MBs) in various biomedical branches has increased over the years [1,2]. They are used, for example, as tracer agents in imaging techniques [3,4], carriers in drug delivery [5,6], and especially as markers in biosensors [7,8]. In the area of biosensing, magnetic beads are used as a separation tool [9] or as markers [10].…”

Section: Introductionmentioning

confidence: 99%

Multiplex Detection of Magnetic Beads Using Offset Field Dependent Frequency Mixing Magnetic Detection

Pourshahidi

Achtsnicht

Nambipareechee

et al. 2021

Sensors

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Magnetic immunoassays employing Frequency Mixing Magnetic Detection (FMMD) have recently become increasingly popular for quantitative detection of various analytes. Simultaneous analysis of a sample for two or more targets is desirable in order to reduce the sample amount, save consumables, and save time. We show that different types of magnetic beads can be distinguished according to their frequency mixing response to a two-frequency magnetic excitation at different static magnetic offset fields. We recorded the offset field dependent FMMD response of two different particle types at frequencies f1 + n⋅f2, n = 1, 2, 3, 4 with f1 = 30.8 kHz and f2 = 63 Hz. Their signals were clearly distinguishable by the locations of the extremes and zeros of their responses. Binary mixtures of the two particle types were prepared with different mixing ratios. The mixture samples were analyzed by determining the best linear combination of the two pure constituents that best resembled the measured signals of the mixtures. Using a quadratic programming algorithm, the mixing ratios could be determined with an accuracy of greater than 14%. If each particle type is functionalized with a different antibody, multiplex detection of two different analytes becomes feasible.

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