Engineering nanoparticle therapeutics for food allergy

Rad, Laila M.; Arellano, Gabriel; Podojil, Joseph R.; O’Konek, Jessica J.; Shea, Lonnie D.; Miller, Stephen D.

doi:10.1016/j.jaci.2023.10.013

Cited by 6 publications

(1 citation statement)

References 103 publications

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“…This is achieved through immune activation by locally delivering anti-inflammatory agents or immunomodulators to regulate immune cell activation. Using the distinctive properties of nanomaterials, the treatment of allergies has been revolutionized providing personalized and effective management of several different types of allergic diseases [ 30 , 31 ]. Table 2 summarizes a comparison of currently available immunotherapy paradigms.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

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Immunotherapy is a rapidly advancing field of research in the treatment of conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery and improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, and inorganic NPs, and discuss their detailed design intricacies, mechanisms, and applications, including the current regulatory issues. This type of nanomaterial design for targeting specific immune cells or tissues and controlling release kinetics could push current technological frontiers and provide new and innovative solutions for immune-related disorders and diseases without off-target effects. These materials enable targeted interactions with immune cells, thereby enhancing the effectiveness of checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Moreover, they allow for fine-tuning of immune responses while minimizing side effects. At the intersection of nanotechnology and immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy and reshape disease management. By prioritizing safety, customization, and compliance with regulatory standards, these systems can make significant contributions to precision medicine, thereby significantly impacting the healthcare landscape.

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Section: Introductionmentioning

confidence: 99%

Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Aljabali,

Obeid,

Gammoh

et al. 2024

Cancers

View full text Add to dashboard Cite

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Engineered Nanoparticles for Theranostic Applications in Kidney Repair

Jin,

Xue,

Zhang

et al. 2024

Adv Healthcare Materials

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Kidney diseases are characterized by their intricate nature and complexity, posing significant challenges in their treatment and diagnosis. Nanoparticles (NPs), which can be further classified as synthetic and biomimetic NPs, have emerged as promising candidates for treating various diseases. In recent years, the development of engineered nanotherapeutics has focused on targeting damaged tissues and serving as drug delivery vehicles. Additionally, these NPs have shown superior sensitivity and specificity in diagnosis and imaging, thus providing valuable insights for the early detection of diseases. This review aims to focus on the application of engineered synthetic and biomimetic NPs in kidney diseases in the aspects of treatment, diagnosis, and imaging. Notably, the current perspectives and challenges are evaluated, which provide inspiration for future research directions, and encourage the clinical application of NPs in this field.

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