Engineering of a core-shell polyvinyl alcohol/gelatin fibrous scaffold for dual delivery of Thymus daenensis essential oil and Glycyrrhiza glabra L. extract as an antibacterial and functional wound dressing

Reisi-Vanani, Vahid; Hosseini, Samanesadat; Soleiman-Dehkordi, Ebrahim; Noaien, B. Sahand; Farzan, Mahour; Ebani, Valentina Virginia; Gholipourmalekabadi, Mazaher; Lozano, Karen; Lorigooini, Zahra

doi:10.1016/j.jddst.2023.104282

Cited by 7 publications

(6 citation statements)

References 75 publications

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“…Additionally, the high swelling capacity and presence of moisture in dressings loaded with therapeutic factors can directly and significantly impact the release rate and effectiveness of those therapeutic factors. The swelling efficiency directly relates to the ability to hydrate and stabilize within biological systems . The fabricated wound dressing was incubated in PBS to assess water absorption and swelling over time.…”

Section: Resultsmentioning

confidence: 99%

“…Absorbance at 385 nm was measured using a spectrophotometer to measure W i . EE percentage was calculated using eq , where W t is the total amount of extract in the suspension (before NP formation) and W i is the total amount of drug that remains in the remaining solution (after NP formation). , E E .25em ( % ) = W t − W i normalW t × 100 …”

Section: Methodsmentioning

confidence: 99%

“…EE percentage was calculated using eq 1, where Wt is the total amount of extract in the suspension (before NP formation) and W i is the total amount of drug that remains in the remaining solution (after NP formation). 21,22 W W EE (%) W 100…”

Section: Encapsulation Of Aa Extract In Spi Nanoparticlesmentioning

confidence: 99%

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Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

Esmaeili,

Ghoraishizadeh,

Farzan

et al. 2024

ACS Appl. Bio Mater.

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Chronic wounds, such as diabetic ulcers and pressure sores, pose significant challenges in modern healthcare due to their prolonged healing times and susceptibility to infections. This study aims to engineer a bilayered wound dressing (BLWD) composed of soy protein isolate/collagen with the ability to release Cinnamaldehyde, Artemisia absinthium (AA), and oxygen. Cinnamaldehyde, magnesium peroxide (MgO 2 ), and AA extract were encapsulated. Nanoparticles were evaluated using scanning electron microscopy (SEM), dynamic light scattering, and ZETA potential tests. Swelling, degradation, water vapor penetration, tensile, MTT, SEM, oxygen release, AA extract release, and antibacterial properties were performed. An in vivo study was carried out to assess the final wound dressing under Hematoxiline&Eosin and Masson trichrome staining analysis and compared to a commercial product. According to the results, the synthesized nanoparticles had an average diameter of about 20 nm with a zeta potential in the range of −20 to −30 mV. The layers had uniform and dense surfaces. The maximum swelling and degradation of the dressing was about 130 and 13% respectively. Generally, better mechanical properties were observed in BLWD than in the single-layer case. More than 90% biocompatibility for the wound dressing was reported. The BLWD could inhibit the growth of Gram-positive and Gram-negative microorganisms. Histopathological analysis showed an acceptable wound-healing property. To sum up, the engineered wound dressing can be a good candidate for more clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

Esmaeili,

Ghoraishizadeh,

Farzan

et al. 2024

ACS Appl. Bio Mater.

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“…According to the numerous criteria mentioned, it is quite clear that no substance alone can fulfill all the wound healing requirements. Therefore, different types of nanocomposites have been used in the structure of wound dressings in order to synergize their desired effects 13,14 . Meanwhile, the use of nanofibers in wound dressings has received attention because of their high surface‐to‐volume ratio and porosity 15 .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, different types of nanocomposites have been used in the structure of wound dressings in order to synergize their desired effects. 13,14 Meanwhile, the use of nanofibers in wound dressings has received attention because of their high surface-to-volume ratio and porosity. 15 Utilizing nanofibers, a suitable structure can be prepared to simulate the extracellular matrix, which speeds up wound healing.…”

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confidence: 99%

Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing

Foroozandeh,

Shakiba,

Zamani

et al. 2024

J Biomed Mater Res

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Hyaluronic acid (HA) and chitosan (CS), as natural biomaterials, display excellent biocompatibility and stimulate the growth and proliferation of fibroblasts. Furthermore, nylon 6 (N6) is a low‐cost polymer with good compatibility with human tissues and high mechanical stability. In this study, HA and CS were applied to modify N6 nanofibrous mat (N6/HA/CS) for potential wound dressing. N6/HA/CS nanofibrous composite mats were developed using a simple one‐step electrospinning technique at different CS concentrations of 1, 2, and 3 wt%. The results demonstrated that incorporating HA and CS into N6 resulted in increased hydrophilicity, as well as favorable physical and mechanical properties. In addition, the minimum inhibitory concentration and (MIC) optical density techniques were used to determine the antibacterial properties of N6/HA/CS nanofibrous composite mats, and the results demonstrated that the composites could markedly inhibit the growth of Gram‐positive bacteria Staphylococcus aureus and Gram‐negative bacteria Escherichia coli. Because of its superior mechanical properties, substantial antimicrobial effects, and hydrophilic surface, N6/HA/CS at 2 wt% of CS (N6/HA/CS2) was chosen as the most suitable nanofibrous mat. The swelling, porosity, gel content, and in vitro degradation studies imply that N6/HA/CS2 nanofibrous composite mat has proper moisture retention and biodegradability. Furthermore, the N6/HA/CS2 nanofibrous composite mat was discovered to be nontoxic to L929 fibroblast cells and to even improve cell proliferation. Based on the findings, this research offers a simple and rapid method for creating material that could be utilized as prospective wound dressings in clinical environments.

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Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

Mehvari,

Ramezanzade,

et al. 2024

Coordination Chemistry Reviews

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Engineering of a core-shell polyvinyl alcohol/gelatin fibrous scaffold for dual delivery of Thymus daenensis essential oil and Glycyrrhiza glabra L. extract as an antibacterial and functional wound dressing

Cited by 7 publications

References 75 publications

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia absinthium, and Oxygen

Electrospun nylon 6/hyaluronic acid/chitosan bioactive nanofibrous composite as a potential antibacterial wound dressing

Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

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