Engineering of QbD driven and ultrasonically shaped lyotropic liquid crystalline nanoparticles for Apigenin in the management of skin cancer

Waheed, Ayesha; Zameer, Saima; Sultana, Niha; Ali, Akhter; Aqil, Mohd.; Sultana, Yasmin; Iqbal, Zeenat

doi:10.1016/j.ejpb.2022.10.015

Cited by 24 publications

(12 citation statements)

References 39 publications

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“…In a study provided by Waheed et al, lyotropic liquid crystalline nanoparticles (LLC NPs) containing apigenin (API) were developed using a quality by design (QbD) approach to enable efficient permeation and enhanced bioavailability for dermal delivery. The dose-dependent effectiveness of these API-LLC NPs was demonstrated in melanoma cell lines (B16F10), indicating the potential of these developed nanoparticles to target the deeper skin layers [ 88 , 89 ]. Das S. and his research group loaded apigenin in poly (lactic-co-glycolide) (PLGA) nanoparticles (NAPs) to determine if nano-encapsulation could improve the anti-carcinogenic effect against skin tumors induced by ultraviolet B (UVB) and Benzo(a)pyrene (BaP) and mitigate mitochondrial dysfunction in mice.…”

Section: Discussionmentioning

confidence: 99%

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

Peterle

Sanfilippo

Borgia

et al. 2023

Foods

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Skin cancer is a prevalent type of cancer worldwide and has a high growth rate compared to other diseases. Although modern targeted therapies have improved the management of cutaneous neoplasms, there is an urgent requirement for a safer, more affordable, and effective chemoprevention and treatment strategy for skin cancer. Nutraceuticals, which are natural substances derived from food, have emerged as a potential alternative or adjunctive treatment option. In this review, we explore the current evidence on the use of omega-3 fatty acids and polyphenols (curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein) for the treatment of melanoma and non-melanoma skin cancer (NMSC), as well as in their prevention. We discuss the mechanisms of action of the aforementioned nutraceuticals and their probable therapeutic benefits in skin cancer. Omega-3 fatty acids, curcumin, epigallocatechin gallate, apigenin, resveratrol, and genistein have several properties, among which are anti-inflammatory and anti-tumor, which can help to prevent and treat skin cancer. However, their effectiveness is limited due to poor bioavailability. Nanoparticles and other delivery systems can improve their absorption and targeting. More research is needed to evaluate their safety and effectiveness as a natural approach to skin cancer prevention and treatment. These compounds should not replace conventional cancer treatments, but may be used as complementary therapy under the guidance of a healthcare professional.

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Section: Discussionmentioning

confidence: 99%

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

Peterle

Sanfilippo

Borgia

et al. 2023

Foods

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“…Further, the risk priority number (RPN) was calculated for the given factors equivalent to the product of severity, probability of occurrence, and probability of detectability that facilitated the importance of risk factors such as MAs/PPs, which significantly affect the QAs. 12,21…”

Section: Methodsmentioning

confidence: 99%

“…The RA study was followed by the study of selected critical quality attributes (CQAs), critical material attributes (CMAs), and critical process parameters (CPPs). 12 The approaches followed were a structured optimization process involving statistical, analytical and riskmanagement methodology to ensure the design, development, and quality of this new pharmaceutical product. 13 Hence, the this research presented a proof-of-concept for the development of a novel drug combination of MTF and MI in an MPPs-loaded intravaginal gel for the amelioration of PCOS.…”

Section: Introductionmentioning

confidence: 99%

In silico and in vitro assessment of an optimized QbD-guided myoinositol and metformin-loaded mucus-penetrating particle-based gel for the amelioration of PCOS

Farooq,

Mirza,

Alshetaili

et al. 2024

Nanoscale Adv.

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“…Non-compartment dermatokinetics was used to calculate the concentration of RUT in each sample at each time point. PK solver software was used to estimate dermatokinetic parameters such as Cskin-max, AUC0–8 h, Ke, and Tskin-max [ 37 ]. Validated UV method in methanol was used for the quantification of drug concentration in different skin samples having regression coefficient of 0.9932, limit of detection: 1.310 µg/mL, and limit of quantification: 3.971 µg/mL ( n = 3).…”

Section: Methodsmentioning

confidence: 99%

Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate

Alam,

Sultana,

Rashid

et al. 2023

Gels

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Sunburn is caused by prolonged exposure to ultraviolet (UV) rays from the sun, resulting in redness of the skin as well as tenderness, swelling, and blistering issues. During the healing process, it can cause peeling, irritation, and some long-term effects, including premature aging, pigmentation, and a high risk of skin cancer. Rutin has antioxidant and anti-inflammatory effects, which could potentially reduce inflammation and soothe sunburned skin. The objective of the current proposal is to develop and create carbopol gel-encased glycerosomes for the treatment of sunburn. The Design of Expert (DoE) technique was used to optimize the proposed formulation and was subjected to various characterization parameters such as nanovesicles size, polydispersity index (PDI), surface charge, entrapment efficiency (EE), and surface morphology. The optimized rutin-loaded glycerosomes (opt-RUT-loaded-GMs) were further characterised for drug release, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, and confocal laser scanning microscopy (CLSM). The formulation showed sustained release, greater permeation into the skin, and good antioxidant activity. The dermatokinetic study of opt-RUT-loaded-GMs confirms that the Rutin hydrate had better retention in the epidermis as compared to the dermis, owing to its potential for long lasting protection after topical application. It was observed that the prepared formulation was stable, highly safe, and had good sun protection factor (SPF) values that could be used as a suitable option for topical drug administration to maximize the therapeutic efficacy of the drugs.

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Engineering of QbD driven and ultrasonically shaped lyotropic liquid crystalline nanoparticles for Apigenin in the management of skin cancer

Cited by 24 publications

References 39 publications

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

The Role of Nutraceuticals and Functional Foods in Skin Cancer: Mechanisms and Therapeutic Potential

In silico and in vitro assessment of an optimized QbD-guided myoinositol and metformin-loaded mucus-penetrating particle-based gel for the amelioration of PCOS

Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate

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