Engineering Strategies to Move from Understanding to Steering Renal Tubulogenesis

Abstract

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Dental Pulp Stem Cell-Derived Exosomes Regulate Anti-Inflammatory and Osteogenesis in Periodontal Ligament Stem Cells and Promote the Repair of Experimental Periodontitis in Rats

“…In recent years, cell tissue engineering (CTE) has become a promising tissue repair strategy in which stem cells are one of the basic elements. [6][7][8] Current studies have shown that the therapeutic effect of stem cells is mainly due to the release of paracrine factors. [9][10][11] As one of the most important paracrine mediators, exosomes derived from stem cells play a therapeutic role through immune regulation.…”

Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions

“…Likewise, a cleavable group could allow switching from a stiff hydrogel toward a softer hydrogel over time, which could be advantageous for culturing multicellular structures, which will exert more forces on the material over time (Figure A-2ii). A screening approach combined with artificial intelligence will be key to processing and assessing the performance of a large library of different material combinations on cellular outcome. Joining forces through experiment and modeling will be very important. − The field has made some initial steps toward this direction, where several groups, like the Weil lab, have started to utilize data-mining strategies, Bayesian optimization, or a design of experiments approach to study intermediate-sized data sets. While the native ECM constantly undergoes energy-intensive remodeling and responds to cellular cues, engineered matrices exhibits rudimentary out-of-equilibrium behavior , and cell communication . Out-of-equilibrium information processing and signal transduction within synthetically designed hydrogels remains a significant challenge.…”

“…A screening approach combined with artificial intelligence will be key to processing and assessing the performance of a large library of different material combinations on cellular outcome. Joining forces through experiment and modeling will be very important. − The field has made some initial steps toward this direction, where several groups, like the Weil lab, have started to utilize data-mining strategies, Bayesian optimization, or a design of experiments approach to study intermediate-sized data sets.…”

“…Joining forces through experiment and modeling will be very important. 194 − 196 The field has made some initial steps toward this direction, where several groups, like the Weil lab, have started to utilize data-mining strategies, 197 Bayesian optimization, 198 or a design of experiments approach 199 to study intermediate-sized data sets. While the native ECM constantly undergoes energy-intensive remodeling and responds to cellular cues, engineered matrices exhibits rudimentary out-of-equilibrium behavior 200 , 201 and cell communication.…”

“…Joining forces through experiment and modeling will be very important. 194 − 196 The field has made some initial steps toward this direction, where several groups, like the Weil lab, have started to utilize data-mining strategies, 197 Bayesian optimization, 198 or a design of experiments approach 199 to study intermediate-sized data sets.…”