Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets
Maria Stylianou,
Thomas Kisby,
Despoina Despotopoulou
et al.
Abstract:The glioblastoma (GBM) microenvironment is characterised as immunologically cold, with immunosuppressive components that compromise the efficacy of current immunotherapies. Tumour associated macrophages and microglia (TAMMs) that are activated towards an immunosuppressive, pro-tumoral state have been identified as major contributing factors to the coldness of GBM, while further promoting tumour progression and resistance to therapy. Based on this understanding, strategies such as macrophage reprogramming have … Show more
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