Engipore acts on human bone marrow stem cells

Sollazzo, Vincenzo; Palmieri, Annalisa; Girardi, Ambra; Farinella, Francesca

doi:10.1016/j.sdentj.2010.07.007

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Engipore causes a significant induction of osteoblast transcriptional factors like SP7 and RUNX2 and of the bone-related gene osteocalcin (BGLAP) (22). Furthermore, the Ca/P ratio is practically similar to that present in the human bone.…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Histological evaluation of a biomimetic material in bone regeneration after one year from graft

Figliuzzi

Fazio

Tiano

et al. 2014

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SummaryAim. The use of substitute materials is one of the solutions used in periodontology for the reconstruction of intrabony defects. Advances in scientific research gave rise to a new generation of biomaterials of synthetic origin stoichiometrically unstable and therefore really absorbable. Our research is directed precisely towards a biomaterial synthesis, Engipore® (Finceramica, Faenza, Italy) which is a bone substitute of the latest hydroxyapatite-based generation, that possesses chemical and morphological properties similar to those of natural bone in the treatment of infrabony periodontal defects. Aim of this study was to evaluate the efficacy of Engipore® in the treatment of intrabony periodontal defects. Methods. The study was conducted on 100 parodontopatics patients, which had gingival pockets of at least infrabonies 8/10 mm. The histological evaluation was performed with samples after one year from the graft. Results. The histological samples collected after one year showed an abundant new bone formation, with mature lamellar bone tissue surrounding the residual particles of Engipore® that appear completely osteointegrated. The surrounding connective tissue shows no signs of inflammation. Conclusions. The results obtained in our researchdemonstrated that, after a proper selection of patients and lesions, and applying an adequate surgical technique, this type of biomaterial in the treatment of periodontal defects acts in an optimal manner as a filler inducing the formation of new bone as evidenced by histological examinations.

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Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Histological evaluation of a biomimetic material in bone regeneration after one year from graft

Figliuzzi

Fazio

Tiano

et al. 2014

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“…The molecular mechanism by which this material influences the behaviour of osteoblast inducing proliferation and bone formation is poorly understood. This biomaterial influences the differentiation of adipose derived stem cells by the activation of osteoblast (23,24).…”

Section: Engiporementioning

confidence: 99%

Applications of Biomaterials for Bone Augmentation of Jaws: Clinical Outcomes and in Vitro Studies

Tettamanti

Bassi²,

Trapella

et al. 2017

ORL

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“…The ceramic-based hydroxyapatite bone graft substitute Engipore (provided by Finceramica Faenza S.p.A., Faenza, Italy) consists of porous hydroxyapatite that allows the product to serve as a scaffold to guide bone regeneration, fostering cell attachment and proliferation and promoting osteointegration [15]. The aim of this retrospective study was to analyze the osteointegrative properties of Engipore bone grafts in revision surgery after primary THA.…”

Section: Introductionmentioning

confidence: 99%

Synthetic Bone Grafting in Aseptic Loosening of Acetabular Cup: Good Clinical and Radiological Outcomes in Contained Bone Defects at Medium-Term Follow Up

Parchi

Simonetti

Bonicoli

et al. 2020

IJERPH

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Restoring bone loss is one of the major challenges when facing hip revision surgery. To eliminate the risk of disease transmission and antigenicity of allografts and donor-morbidity of autografts, the use of synthetic bioceramics has become popular in the last decade. Our study investigated the effectiveness of impaction bone grafting (IBG) of contained acetabular defects (Paprosky 2 and 3a) using a porous ceramic-based hydroxyapatite bone substitute (Engipore, provided by Finceramica Faenza S.p.A., Faenza, Italy) mixed with a low percentage of autologous bone (obtained from reaming when available). We retrospectively assessed 36 patients who underwent acetabular revision using IBG using a porous ceramic-based hydroxyapatite bone substitute with cementless implants with a mean follow-up of 4.4 years. We evaluated, at regular intervals, patients clinically (using the Hip Harris Score and Oxford Score) and radiologically to evaluate the rate of incorporation of the graft, the presence of radiolucent lines or migrations of the cup. Clinical scores significantly improved (WOMAC improved from 49.7–67.30, and the HSS from 56–89). The rate of implants’ survival was 100% at our medium follow-up (4.4 years). We reported five cases of minor migration of the cup, and radiolucent lines were visible in seven patients at the last-follow up. The graft was well-incorporated in all patients. The results presented in this study suggest the HA bone substitute is an effective and safe bone graft when facing hip revision surgery; thus, longer follow-up studies are required.

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Engipore acts on human bone marrow stem cells

Abstract: The obtained results can be relevant to better understand the molecular mechanism of bone regeneration.

Cited by 5 publications

References 27 publications

Histological evaluation of a biomimetic material in bone regeneration after one year from graft

Histological evaluation of a biomimetic material in bone regeneration after one year from graft

Applications of Biomaterials for Bone Augmentation of Jaws: Clinical Outcomes and in Vitro Studies

Synthetic Bone Grafting in Aseptic Loosening of Acetabular Cup: Good Clinical and Radiological Outcomes in Contained Bone Defects at Medium-Term Follow Up

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