Enhanced antimicrobial activity through the combination of antimicrobial photodynamic therapy and low-frequency ultrasonic irradiation

Wang, Ying; Xu, Yixuan; Guo, Xianghuan; Wang, Lei; Zeng, Jing; Qiu, Haixia; Tan, Ying; Chen, Defu; Zhao, He; Gu, Ying

doi:10.1016/j.addr.2022.114168

Cited by 38 publications

(23 citation statements)

References 74 publications

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“…Antibacterial nanotherapeutic strategies have been highlighted in the literature ac-cording to their mechanisms. Recently, Wang et al reviewed nanocarriers for antibacterial agents, including inorganic nanoparticles (NPs), polymeric NPs, and metal-organic framework structures (MOFs) that exhibit intrinsic antibacterial activity and may lead to more potent activity, as well as for decreasing the occurrence of antibiotic resistance [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity

et al. 2023

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Numerous antimicrobial drugs have been prescribed to kill or inhibit the growth of microbes such as bacteria, fungi, and viruses. Despite the known therapeutic efficacy of these drugs, inefficient delivery could result in an inadequate therapeutic index and several side effects. In order to overcome this adversity, the present study investigated antibiotic drug loading in zeolitic imidazolate frameworks (ZIFs), in association with ZnO nanoparticles with known antimicrobial properties. In an economic synthesis method, the ZnO surface was first converted to ZIF-8 with 2-methylimidazole as a ligand, resulting in a ZnO@ZIF-8 structure. This system enables the high drug-loading efficiency (46%) of an antimicrobial drug, ciprofloxacin, within the pores of the ZIF-8. This association provides a control of the release of the active moieties, in simulated body-fluid conditions, with a maximum of 67% released in 96 h. The antibacterial activities of ZnO@ZIF-8 and CIP-ZnO@ZIF-8 were tested against the Gram-positive Staphylococcus aureus strain and the Gram-negative Pseudomonas aeruginosa strain, showing good growth inhibition. This result was obtained by combining ZnO@ZIF-8 with ciprofloxacin in a minimal inhibitory concentration (MIC) that was 10 times lower than ZnO@ZIF-8 for S. aureus and 200 times lower for P. aeruginosa, suggesting that CIP-ZnO@ZIF-8 may have potential application in prolonged antimicrobial treatment.

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Section: Introductionmentioning

confidence: 99%

ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity

et al. 2023

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“…Enhanced antimicrobial activity was obtained through the combination of aPDT and low-frequency ultrasonic irradiation [ 259 ]. Ultrasound irradiation bears a deeper penetration in human tissues than light and, sequentially, can promote drug delivery through the cavitation effect.…”

Section: Smart Dental Materials For Antimicrobial and Antibiofilm The...mentioning

confidence: 99%

Smart dental materials for antimicrobial applications

Montoya

Roldán

et al. 2023

Bioactive Materials

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“…1 Accordingly, that leads to the appearance of infections, caused by bacteria, which are resistant to the implemented medications. [2][3][4] Because of this reason, the spreading of resistant and particularly polyresistant microorganisms, has been a huge challenge to treat such infections. That requires intensive investigation of new highly effective substances exhibiting antimicrobial activity in clinical practice and research on new strategies for dealing with antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

“…In the recent years, the world has been seriously affected by the decrease of antibiotic efficiency due to the emerging resistance of the pathogenic microorganisms towards the antibiotics used in clinical practice 1 . Accordingly, that leads to the appearance of infections, caused by bacteria, which are resistant to the implemented medications 2–4 . Because of this reason, the spreading of resistant and particularly polyresistant microorganisms, has been a huge challenge to treat such infections.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the antibacterial activity of PAMAM dendrimer modified with 1,8‐naphthalimides and its copper complex via light illumination

Staneva

Manov

Vasileva−Tonkova

et al. 2022

Polymers for Advanced Techs

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This work describes the synthesis of a new photoactive PAMAM dendrimer of first generation, modified with 4‐dimethylamino‐1,8‐naphthalimide units and its complexation with Cu2+ ions. The photophysical characteristics of the two compounds in organic solvents of different polarity have been determined. The impact of light on reactive oxygen species from the new compounds and on the cotton fabrics dyed with them has been investigated by an iodometric method, consisting of I− transformation into I3−, which absorbs light at 288 and 352 nm. It has been determined that their antibacterial activity towards Gram‐negative and Gram‐positive bacteria enhances upon light illumination, as a resultant synergic effect of the biological activity of the new dendrimers and of the reactive oxygen they generate. The copper complex has been found to be more active than the ligand. Upon their loading onto cotton fabrics both compounds retain their antibacterial activity.

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Enhanced antimicrobial activity through the combination of antimicrobial photodynamic therapy and low-frequency ultrasonic irradiation

Cited by 38 publications

References 74 publications

ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity

ZnO@ZIF-8 Nanoparticles as Nanocarrier of Ciprofloxacin for Antimicrobial Activity

Smart dental materials for antimicrobial applications

Enhancing the antibacterial activity of PAMAM dendrimer modified with 1,8‐naphthalimides and its copper complex via light illumination

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