Enhanced Ascorbyl Palmitate Stability by Polymeric Nanoparticles

Tangsumranjit, Anothai; Pellequer, Yann; Lboutounne, H.; Guillaume, Yves Claude; Lamprecht, Alf; Millet, J.

doi:10.1016/s1773-2247(06)50025-5

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…In addition, the shell performs a release mechanism to control the diffusion level of active molecules under specific conditions, resulting in prolonged activities of these molecules. A few materials such as lipids [3][4][5][6], poly(d,l-lactide) [7], and poly(d,l-lactide-co-glycolide) [7] have been used as encapsulants for AP in the forms of microemulsions [3], liposomes [3,5,8], solid lipid nanoparticles [3], nanostructured lipid carriers [4,6] and nanoparticles [7]. In addition, the nano-level encapsulation would likely enhance the bioavailability of lipophilic compounds, thus increasing the degree to which those compounds become available to the target tissues.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes

Yoksan

Jirawutthiwongchai

Arpo

2010

Colloids and Surfaces B: Biointerfaces

251

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Section: Introductionmentioning

confidence: 99%

Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes

Yoksan

Jirawutthiwongchai

Arpo

2010

Colloids and Surfaces B: Biointerfaces

251

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“…The degree of skin moisturizing and penetration of ASC-P entrapped in SLN, NLC, and NE incorporated into hydrogel was significantly higher compared to that of NE [ 21 ]. Enhanced stability of ASC-P encapsulated in poly(D,L-lactide) (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles was reported by Tangsumranjit et al [ 22 ]. In ASC-P-encapsulated PLA nanoparticles, ionic strength, and the degassing step affected ASC-P stability.…”

Section: Introductionmentioning

confidence: 99%

Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives

Moribe

Limwikrant

Higashi

et al. 2011

Journal of Drug Delivery

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Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food and pharmaceutical excipients. In addition to drug solubilization, drug nanoparticle formation was observed using ascorbyl glycoside. Hydrophobic ascorbic acid derivatives such as ascorbyl mono- and di-n-alkyl fatty acid derivatives are used either as drugs or carrier components. Ascorbyl n-alkyl fatty acid derivatives have been formulated as antioxidants or anticancer drugs for nanoparticle formulations such as micelles, microemulsions, and liposomes. ASC-P vesicles called aspasomes are submicron-sized particles that can encapsulate hydrophilic drugs. Several transdermal and injectable formulations of ascorbyl n-alkyl fatty acid derivatives were used, including ascorbyl palmitate.

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“…The flow rate was 1 ml min −1 . The UV detector was set at the wavelength of 254 nm and the injection volume was 20 µL [23,24].…”

Section: Encapsulation Efficiency Of Ascorbyl Palmitate In Electrospun Zein Fibersmentioning

confidence: 99%

“…At the intervals of 15, 30, 45, 60, 90, 120, and 180 minutes, 200µL of the sample was carefully replaced by the same amount of the fresh medium. The amount of the released AP was determined by RP-HPLC [9,23,24].…”

Section: Release Analysismentioning

confidence: 99%

“…According to the results, encapsulation efficiency increased significantly (p < 0.05) when AP concentration was increased from 2.5 to 10% w/v. The inconsistency from the ideal value of 100% for these samples could be due to the failure of homogenous distribution of AP in the electrospun fibers, which could be influenced by the fabrication techniques [22], and degradation of AP in different steps of production, and storage of loaded electrospun zein fibers, because of its sensitivity to oxygen [23,31]. Kim et al [32] loaded ascorbyl pamitate in chitosan nanoparticles and reported the entrapment efficiency was 49%.…”

Section: Encapsulation Efficiency Of Ap In Electrospunzein Fibersmentioning

confidence: 99%

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Encapsulation of Ascorbyl Palmitate in Zein by Electrospinning Technique

et al. 2020

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In this study, ascorbyl palmitate was encapsulated in electrospun zein fibers at different loading levels (2.5%w/v, 5%w/v and 10% w/v). HPLC, SEM, FTIR, XRD, DSC and BET characterized the resulting electrospun zein fibers containing ascorbyl palmitate. Results indicated that the diameters of electrospun zein fibers increased with increasing concentration of ascorbyl palmitate. The physical status of ascorbyl palmitate in electrospun zein fibers was determined by X-ray diffraction (XRD), and differential scanning calorimetry (DSC). Fourier transform infrared (FTIR) was used to study the interaction between ascorbyl palmitate, and zein. The results showed that there was hydrogen bonding between protein and ascorbyl palmitate. Pore size was characterized by N 2 adsorption-desorption isotherms. Contact angle results showed that hydrophobicity of electrospun fiber mats was not affected by ascorbyl palmitate. Encapsulation efficiency of ascorbyl palmitate in electrospun zein fibers was about 22.5-65.5% w/v. Release study results indicated that pH and morphology affected the release. This is the first report describing that ascorbyl palmitate was successfully encapsulated in electrospun zein fibers. This product is intended to be used as an active coating for the delivery of ascorbyl palmitate to butter and other food products.

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Enhanced Ascorbyl Palmitate Stability by Polymeric Nanoparticles

Cited by 6 publications

References 11 publications

Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes

Encapsulation of ascorbyl palmitate in chitosan nanoparticles by oil-in-water emulsion and ionic gelation processes

Drug Nanoparticle Formulation Using Ascorbic Acid Derivatives

Encapsulation of Ascorbyl Palmitate in Zein by Electrospinning Technique

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