Enhanced bioavailability and retinal accumulation of lutein from self-emulsifying phospholipid suspension (SEPS)

Shanmugam, Sumathi; Park, Jae Hyun; Kim, Kyeong Soo; Piao, Zong Zhu; Yong, Chul Soon; Choi, Han Gon; Woo, Jong Soo

doi:10.1016/j.ijpharm.2011.04.015

Cited by 51 publications

(17 citation statements)

References 33 publications

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“…Phospholipids are endogenous lipid with efficient in vivo emulsification capability. These require relatively low amount of surfactant/cosurfactant and thus posing less health problems [83]. …”

Section: Dosage Forms From Self-emulsifying Systemsmentioning

confidence: 99%

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

2013

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Poorly water-soluble drug candidates are becoming more prevalent. It has been estimated that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous media and/or have very low permeability to allow for their adequate and reproducible absorption from the gastrointestinal tract (GIT) following oral administration. Formulation scientists have to adopt various strategies to enhance their absorption. Lipidic formulations are found to be a promising approach to combat the challenges. In this review article, potential advantages and drawbacks of various conventional techniques and the newer approaches specifically the self-emulsifying systems are discussed. Various components of the self-emulsifying systems and their selection criteria are critically reviewed. The attempts of various scientists to transform the liquid self-emulsifying drug delivery systems (SEDDS) to solid-SEDDS by adsorption, spray drying, lyophilization, melt granulation, extrusion, and so forth to formulate various dosage forms like self emulsifying capsules, tablets, controlled release pellets, beads, microspheres, nanoparticles, suppositories, implants, and so forth have also been included. Formulation of SEDDS is a potential strategy to deliver new drug molecules with enhanced bioavailability mostly exhibiting poor aqueous solubility. The self-emulsifying system offers various advantages over other drug delivery systems having potential to solve various problems associated with drugs of all the classes of biopharmaceutical classification system (BCS).

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Section: Dosage Forms From Self-emulsifying Systemsmentioning

confidence: 99%

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

2013

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“…These strategies have been designed to avoid excessive amounts of surfactants and co-surfactants that possess potential solubilization problems upon storage and possible gastrointestinal irritation in vivo. SEPS consist of high amounts of phospholipid and relatively low amounts of surfactant or cosurfactant formulations [65]. On the other hand, S-SNEDDS incorporate liquid excipients into powders by solidification [66].…”

Section: Xanthophyll Formulations Not Yet Studied For Xanthophyll Stamentioning

confidence: 99%

“…SEPS formulations are prepared through homogenization at ambient temperature, while S-SNEDDS formulations are obtained through spray dry technology; making the last one a high energy process. Both strategies have been employed for lutein bioavailability studies [65,66], where a higher relative bioavailability was observed (Tab. 3).…”

Section: Xanthophyll Formulations Not Yet Studied For Xanthophyll Stamentioning

confidence: 99%

Purification and Formulation of Xanthophyll for Pharmaceutical Use: Current Strategies and Future Trends

2015

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The increasing attention to biological activities of dietary xanthophylls demands the establishment of attractive and easy-to-implement purification protocols for their recovery from different sources. Bioengineering strategies that involve alternative isolation and purification techniques have gained interest since they offer practical benefits in comparison to traditional column chromatography methods. Furthermore, the use of these techniques has resulted in compound purities from 50 to 98 %. Besides purification, it is important to keep in mind that xanthophyll bioavailability is limited due to their low solubility in digestive fluids. Therefore, there is also the need to enhance xanthophyll bioavailability through formulations of the purified compounds. Several formulation techniques have been employed to obtain products for bioavailability or stability studies. However, there is a lack of studies that address the effect of the formulation upon the bioavailability and stability of these compounds. In the present review, emerging purification and formulation technologies that have shown potential for xanthophyll isolation and bioavailability enhancement are critically discussed. This analysis is presented in order to discuss the current trends in the purification and formulation technologies of xanthophylls, particularly for pharmaceutical use.

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“…Pesquisas utilizando-se de luteína mostram que é benéfica para a performance visual (KVANSAKUL et al, 2006;SHANMUGAM et al, 2011). Dentre 600 carotenóides, tem se destacado pela sua habilidade reduzir o risco de ocorrência de doenças oculares, como por exemplo, a degeneração macular senil (BIAN et al, 2012).…”

Section: Carotenoidesunclassified

Nutracêuticos imunomoduladores com potencial uso clínico para cães e gatos

et al. 2014

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ResumoTem-se observado o uso crescente de nutracêuticos em medicina veterinária, para auxiliar no tratamento clínico. Esta revisão teve como objetivo descrever alguns nutracêuticos que atuam sobre a imunidade de cães e gatos e levantar os possíveis benefícios como tratamento adjuvante para determinadas enfermidades. A ação de derivados de levedura tem sido bastante avaliada, especialmente da fração beta-glucano, um potente imunomodulador, com ação já demonstrada em cães e gatos, sendo benéfico no tratamento de algumas doenças. Os ácidos graxos poliinsaturados ômega-3, talvez os mais utilizados atualmente, podem trazer benefícios no tratamento de hipertensão, doenças renais e cardíacas, artrites, doenças autoimunes, doenças gastrintestinais e câncer. A vitamina E apresenta ação antioxidante e imunomoduladora, podendo auxiliar no tratamento de doenças dermatológicas e hepatobiliares. O uso de carotenoides, que tem ação semelhante à da vitamina E, pode ser interessante por serem potentes antioxidantes, podem ajudar na melhora da resposta imune contra microrganismos e, também, na prevenção do aparecimento de tumores. Apesar de ainda serem necessários mais estudos clínicos para se entender os reais benefícios trazidos pela suplementação dos nutracêuticos em cada doença específica, a compreensão dos mecanismos de ação destes indica que são promissores para uso clínico. Palavras-chave: Ácidos graxos poliinsaturados ômega-3, Beta-glucano, carotenoides, imunidade, vitamina E AbstractThe use of nutraceuticals in veterinary medicine is growing and is assumed that they could aid in clinical treatment. This review aims to describe some nutraceuticals that act on the immunity of dogs and cats and show the possible benefits as an adjuvant treatment for some diseases. The action of some yeast derivates as immunomodulators, especially the beta-glucan fraction, was already proved to occur in dogs and cats, being beneficial as an adjuvant therapy in many clinical conditions. Omega-3 polyunsatured fatty acids, possibly the mostly used nutraceuticals, can improve the condition in some diseases, such as hypertension, renal, cardiac, gastrointestinal and autoimmune diseases, arthritis and cancer. Vitamin E has antioxidant and immunomodulatory action and can aid in the treatment

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Enhanced bioavailability and retinal accumulation of lutein from self-emulsifying phospholipid suspension (SEPS)

Cited by 51 publications

References 33 publications

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

Purification and Formulation of Xanthophyll for Pharmaceutical Use: Current Strategies and Future Trends

Nutracêuticos imunomoduladores com potencial uso clínico para cães e gatos

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