Enhanced detection of the potential electroactive label methylene blue by electrode nanostructuration with carbon nanotubes

García-González, Raquel; Costa-Garcı́a, Agustı́n; Fernández‐Abedul, M. Teresa

doi:10.1016/j.snb.2014.04.104

Cited by 21 publications

(11 citation statements)

References 33 publications

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“…“Traditional” metal nanoparticles (such as gold nanoparticles or quantum dots), carbon structures (such as CNTs or graphene) and other state‐of‐the‐art micro/nanostructures are used for signal amplification as i) carriers of bioreagents (by decreasing the diffusion path of the target molecules and increasing the binding sites in bead‐based systems), ii) bulk and surface modifiers (for instance, by increasing the selectivity of sensors or favoring electron transfer in electrochemical sensors), iii) labels in bioassays (such as magnetic nanoparticles or fluorescent quantum dots), and iv) tools for enhancing the signal generating events, simply by a chemical reaction (for example, reduction of silver ions on gold nanoparticles), or for increasing the number of signaling components (such as beads, micro/nanoparticles or nanovesicles with labels). The underlying mechanisms of different applications using micro‐ and nanostructures are depicted in Figure .…”

Section: Recognition Elements Amplification Methods and Sensor Intementioning

confidence: 99%

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

et al. 2019

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Disposable sensors are low‐cost and easy‐to‐use sensing devices intended for short‐term or rapid single‐point measurements. The growing demand for fast, accessible, and reliable information in a vastly connected world makes disposable sensors increasingly important. The areas of application for such devices are numerous, ranging from pharmaceutical, agricultural, environmental, forensic, and food sciences to wearables and clinical diagnostics, especially in resource‐limited settings. The capabilities of disposable sensors can extend beyond measuring traditional physical quantities (for example, temperature or pressure); they can provide critical chemical and biological information (chemo‐ and biosensors) that can be digitized and made available to users and centralized/decentralized facilities for data storage, remotely. These features could pave the way for new classes of low‐cost systems for health, food, and environmental monitoring that can democratize sensing across the globe. Here, a brief insight into the materials and basics of sensors (methods of transduction, molecular recognition, and amplification) is provided followed by a comprehensive and critical overview of the disposable sensors currently used for medical diagnostics, food, and environmental analysis. Finally, views on how the field of disposable sensing devices will continue its evolution are discussed, including the future trends, challenges, and opportunities.

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Section: Recognition Elements Amplification Methods and Sensor Intementioning

confidence: 99%

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

et al. 2019

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“…A third possible approach for signal amplification is the use of nanomaterials as electrode surface modifiers that can favour the electron transfer. Therefore, the modification of the paper-based WE with carbon nanomaterials (carbon nanotubes and nanofibers) was considered since they have demonstrated to improve the electron transfer and therefore, the current intensity of redox processes [60][61][62]. The paper-based WEs were modified with MWCNTs and CNFs dispersions (as explained in Section 2.4) with the aim of amplifying the DCF's anodic process of interest.…”

Section: Preconcentration and Improvement Of The Analytical Signalmentioning

confidence: 99%

Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform

Costa‐Rama

Nouws

Delerue–Matos

et al. 2019

Analytica Chimica Acta

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This work describes the development of a paper-based platform for highly sensitive detection of diclofenac. The quantification of this anti-inflammatory drug is of importance in clinical (e.g. quality-and therapeutic control) and environmental (e.g. emerging contaminant determination) areas. The easy-to-handle platform here described consists of a carbon-ink paper-based working electrode and two metallic wires, provided by a gold-plated standard connector, as reference and counter electrodes. The porous paper matrix enables the preconcentration of the sample, decoupling sample and detection solutions. Thus, relatively large sample volumes can be used, which significantly improves the sensitivity of the method. A wide dynamic range of four orders of magnitude, between 0.10 and 100 µM, was obtained for diclofenac determination. Due to the predominance of adsorption at the lowest concentrations, there were two linear concentration ranges: one comprised between 0.10 and 5.0 µM (with a slope of 0.85 µA µM-1) and the other between 5.0 and 100 µM (with a slope of 0.48 µA µM-1). A limit of detection of 70 nM was achieved with this simple device. The platform provided accurate results with an RSD of ca. 5%. It was applied for diclofenac quantification in spiked tap water samples. The versatility of this design enabled the fabrication of a multiplexed platform containing eight electrochemical cells that work independently. The low cost, small size and simplicity of the device allow on-site analysis, which is very useful for environmental monitoring.

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“…25 The effective surface area of po-SPCEs was measured in 10 mmol L -1 PBS containing 5 mmol L -1 Fe(CN)6 4-in the potential range of -0.1 to 0.5 V to obtain the relationship between the anodic peak current (Ipa) of Fe (CN)6 4-and the square root of the scanning rate (ν 1/2 ). 28 According to the Randles-Sevcik equation, Ipa = (2.69 × 10 5 )n 3/2 AD 1/2 Cν 1/2 , where n (= 1) is the electron-transferred number, D (= 6.5 × 10 -6 cm 2 s -1 ) is the diffusion coefficient of Fe(CN)6 4-, C (5 mmol L -1 ) is the molar concentration and A is the effective surface area (cm 2 ); A can be calculated from the slope of Ipa versus ν 1/2 . Furthermore, the electrodes' roughness factor was defined as the ratio of the measured effective area to the geometrical area.…”

Section: Spce Preoxidationmentioning

confidence: 99%

Effect of the Chain Length of a Modified Layer and Surface Roughness of an Electrode on Impedimetric Immunosensors

Lin

2017

ANAL. SCI.

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An ultrasensitive label-free impedimetric immunosensor is constructed by modifying a 3-mercaptoproponic acid (MPA) monolayer on highly rough gold nanostructure (AuNS)-electrodeposited screen printed carbon electrodes (SPCEs) for the detection of small molecular weight drugs (SMWDs), such as salbutamol (SAL). The SPCEs preoxidized in a 0.1 M H2SO4 solution (called po-SPCEH2SO4) are electrodeposited with the AuNS to increase the roughness factor to 23.64 ± 1.76, larger than the AuNS/po-SPCENaOH or the AuNS/po-SPCEPBS. Furthermore, the MPA modified layer as a link for the anti-SAL immobilization to give the immunosensors an impedimetric signal-to-noise ratio larger than the 11-mercaptoundecanoic acid-and 16-mercaptohexadecanoic acid-modified layer, due to the lower interfacial impedance of the MPA monolayer. The MPA/AuNS/po-SPCEH2SO4-based immunosensors have a wide linear range of 1 fg mL -1 to 1 ng mL -1 and a limit of detection of 0.6 fg mL -1 . Moreover, the immunosensors can practically quantify the SAL concentrations in 1000 times-diluted serum samples with good recovery.

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Enhanced detection of the potential electroactive label methylene blue by electrode nanostructuration with carbon nanotubes

Cited by 21 publications

References 33 publications

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

Disposable Sensors in Diagnostics, Food, and Environmental Monitoring

Preconcentration and sensitive determination of the anti-inflammatory drug diclofenac on a paper-based electroanalytical platform

Effect of the Chain Length of a Modified Layer and Surface Roughness of an Electrode on Impedimetric Immunosensors

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