In perturbative QCD approach, based on the first order of isospin symmetry breaking, we study the direct
CP
violation in the decay of
B
¯
s
0
⟶
ρ
ω
K
∗
0
⟶
π
+
π
−
K
∗
0
. An interesting mechanism is applied to enlarge the
C
P
violating asymmetry involving the charge symmetry breaking between
ρ
and
ω
. We find that the
CP
violation is large by the
ρ
−
ω
mixing mechanism when the invariant masses of the
π
+
π
−
pairs are in the vicinity of the
ω
resonance. For the decay process of
B
¯
s
0
⟶
ρ
ω
K
∗
0
⟶
π
+
π
−
K
∗
0
, the maximum
CP
violation can reach
−
59.12
%
. Furthermore, taking
ρ
−
ω
mixing into account, we calculate the branching ratio for
B
¯
s
0
⟶
ρ
ω
K
∗
0
. We also discuss the possibility of observing the predicted
C
P
violation asymmetry at the LHC.