Enhanced effect of β-tricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics: In vitro and in vivo evidence

Chen, Y.; Wang, J.; Zhu, Xiangdong; Tang, Zhurong; Yang, Xiao; Tan, Yan Fei; Fan, Yujiang; Zhang, X.D.

doi:10.1016/j.actbio.2014.09.028

Cited by 112 publications

(106 citation statements)

References 65 publications

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“…Angiogenesis requires a dynamic and temporally and spatially regulated interaction between endothelial cells, angiogenic factors and surrounding extracellular matrix proteins since vascularization is an important in skin substitutes fabrication [22,23]. In this case, for biocompatibility, HUVECs were selected to detect if this scaffold could support cell proliferation, migration and further angiogenesis related gene secretion.…”

Section: Cross-linkers In Collagen Based Scaffold Fabrication Previomentioning

confidence: 99%

HPLC detection of loss rate and cell migration of HUVECs in a proanthocyanidin cross-linked recombinant human collagen-peptide (RHC)–chitosan scaffold

Zhang

Deng

Yang

et al. 2015

Materials Science and Engineering: C

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Section: Cross-linkers In Collagen Based Scaffold Fabrication Previomentioning

confidence: 99%

HPLC detection of loss rate and cell migration of HUVECs in a proanthocyanidin cross-linked recombinant human collagen-peptide (RHC)–chitosan scaffold

Zhang

Deng

Yang

et al. 2015

Materials Science and Engineering: C

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“…Therefore, we presumed that the bioactivity of β-TCP nanoparticles is site specific. Furthermore, β-TCP in combination with several growth factors promoted prominent bone formation as well as cell proliferation and neovascularization 50,51) . Therefore, additional investigations must be conducted to facilitate further development of β-TCP nanoparticle therapy.…”

Section: Discussionmentioning

confidence: 99%

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

et al. 2017

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Three-dimensional collagen scaffolds coated with beta-tricalcium phosphate (β-TCP) nanoparticles reportedly exhibit good bioactivity and biodegradability. Dose effects of β-TCP nanoparticles on biocompatibility and bone forming ability were then examined. Collagen scaffold was applied with 1, 5, 10, and 25 wt% β-TCP nanoparticle dispersion and designated TCP1, TCP5, TCP10, and TCP25, respectively. Compressive strength, calcium ion release and enzyme resistance of scaffolds with β-TCP nanoparticles applied increased with β-TCP dose. TCP5 showed excellent cell-ingrowth behavior in rat subcutaneous tissue. When TCP10 was applied, osteoblastic cell proliferation and rat cranial bone augmentation were greater than for any other scaffold. The bone area of TCP10 was 7.7-fold greater than that of non-treated scaffold. In contrast, TCP25 consistently exhibited adverse biological effects. These results suggest that the application dose of β-TCP nanoparticles affects the scaffold bioproperties; consequently, the bone conductive ability of TCP10 was remarkable.

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“…Ionic release of these materials can stimulate angiogenesis both in vivo and in vitro [9]. Calcium is one of the ions reported to stimulate the formation of vessels [35–38]. In fact, calcium, calcium-releasing bioglasses and glass-ceramics promote angiogenesis in vitro by increasing proliferation and tube formation in EPCs and human umbilical endothelial cells (HUVEC) [35,36].…”

Section: Introductionmentioning

confidence: 99%

“…Calcium is one of the ions reported to stimulate the formation of vessels [35–38]. In fact, calcium, calcium-releasing bioglasses and glass-ceramics promote angiogenesis in vitro by increasing proliferation and tube formation in EPCs and human umbilical endothelial cells (HUVEC) [35,36]. In addition, composite materials of calcium-releasing bioglasses and polymeric matrices such as poly(lactic acid) and poly(caprolactone) promote blood vessel formation in vivo [37,38].…”

Section: Introductionmentioning

confidence: 99%

PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation

et al. 2018

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Increasing blood vessel formation in diseased tissues with poor vascularization is a current clinical challenge. Cell therapy using human mesenchymal stem cells has received considerable interest, but low cell survival has hampered its translation to the clinic. Bioglasses and glass-ceramics have been explored as therapeutic agents for stimulating angiogenesis in soft tissues, but these effects need further evaluation in vivo. By incorporating both human mesenchymal stem cells and glass-ceramic particles in an implantable hydrogel, this study provides insights into the vasculogenic potential in soft tissues of the combined strategies. Enhancement of vessel formation and maturation supports further investigation of this strategy.

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Enhanced effect of β-tricalcium phosphate phase on neovascularization of porous calcium phosphate ceramics: In vitro and in vivo evidence

Cited by 112 publications

References 65 publications

HPLC detection of loss rate and cell migration of HUVECs in a proanthocyanidin cross-linked recombinant human collagen-peptide (RHC)–chitosan scaffold

HPLC detection of loss rate and cell migration of HUVECs in a proanthocyanidin cross-linked recombinant human collagen-peptide (RHC)–chitosan scaffold

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation

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