2017
DOI: 10.1016/j.jsxm.2017.09.013
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Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries

Abstract: Background The internal pudendal arteries (IPA) supply blood to the penis and are highly susceptible to vascular remodeling in rodent models of diabetes, hypertension, aging, and chronic kidney disease contributing to erectile dysfunction (ED). Interestingly, vascular remodeling primarily occurs in the distal and not in the proximal IPA suggesting that there are distinct local physiological signaling differences within the IPA. Aim To examine the role of purinergic signaling and electrical field stimulated (… Show more

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Cited by 5 publications
(2 citation statements)
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“…the primary arteries supplying blood to the penis and contributing most of the vascular resistance to the penis, with the distal IPA displaying neurovascular regulation that most resembles that of the penis. 56,57 The vascular endothelium plays an important role in regulating penile vascular tone and promoting erection mainly through the production of nitric oxide, which mediates smooth muscle relaxation and increased blood flow to the penis. Notably, endothelial dysfunction has been shown to reduce the bioavailability of nitric oxide, blood inflow, and to be a prominent factor in erectile dysfunction.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…the primary arteries supplying blood to the penis and contributing most of the vascular resistance to the penis, with the distal IPA displaying neurovascular regulation that most resembles that of the penis. 56,57 The vascular endothelium plays an important role in regulating penile vascular tone and promoting erection mainly through the production of nitric oxide, which mediates smooth muscle relaxation and increased blood flow to the penis. Notably, endothelial dysfunction has been shown to reduce the bioavailability of nitric oxide, blood inflow, and to be a prominent factor in erectile dysfunction.…”
Section: Discussionmentioning
confidence: 99%
“…Erectile dysfunction can be caused by any of the multi factors acting on the regulation of the smooth muscle contraction and relaxation in the vessels supplying the penis. The internal pudendal arteries (IPA) have been shown to be the primary arteries supplying blood to the penis and contributing most of the vascular resistance to the penis, with the distal IPA displaying neurovascular regulation that most resembles that of the penis 56,57 . The vascular endothelium plays an important role in regulating penile vascular tone and promoting erection mainly through the production of nitric oxide, which mediates smooth muscle relaxation and increased blood flow to the penis.…”
Section: Discussionmentioning
confidence: 99%