Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice

Wu, Yuqing; Zhang, Rongjian; Zhou, Chenghua; Xu, Youhua; Guan, Xiaowei; Hu, Jue; Xu, Yinyan; Li, Shengnan

doi:10.1016/j.atherosclerosis.2008.05.059

Cited by 23 publications

(18 citation statements)

References 34 publications

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“…Similarly, changes in gene expression of stress-signaling receptors were not observed in the colon of naïve or NMS mice. The current study revealed an overall negative impact of NMS on colorectal sensitivity, both at baseline and following WAS, which is contradictory to previous studies using a 14d-long NMS protocol in either rats (Coutinho et al, 2002; O’Malley et al, 2011; Wu et al, 2009) or mice (Moloney et al, 2012) and suggests that a three-week long NMS protocol in female mice may generate a hypersensitive phenotype that, among the pelvic viscera, is restricted to the urogenital organs (Pierce et al, 2014). This observation highlights the importance of noting the duration of stress and the strain and sex of the animal used across differing NMS protocols.…”

Section: Discussioncontrasting

confidence: 99%

Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress

et al. 2016

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Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We examined the impact of neonatal maternal separation (NMS) on bladder sensitivity and visceral neuroimmune status both prior-to, and following, water avoidance stress (WAS) in adult female mice. The visceromotor response to urinary bladder distension was increased at baseline and 8d post-WAS in NMS mice, while colorectal sensitivity was transiently increased 1d post-WAS only in naïve mice. Bladder micturition rate and output, but not fecal output, were also significantly increased following WAS in NMS mice. Changes in gene expression involved in regulating the stress response system were observed at baseline and following WAS in NMS mice, and WAS reduced serum corticosterone levels. Cytokine and growth factor mRNA levels in the bladder, and to a lesser extent in the colon, were significantly impacted by NMS and WAS. Peripheral mRNA levels of stress-responsive receptors were differentially influenced by early life and adult stress in bladder, but not colon, of naïve and NMS mice. Histological evidence of mast cell degranulation was increased in NMS bladder, while protein levels of protease activated receptor 2 (PAR2) and transient receptor potential ankyrin 1 (TRPA1) were increased by WAS. Together, this study provides new insight into mechanisms contributing to stress associated symptom onset or exacerbation in patients exposed to early life stress.

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Section: Discussioncontrasting

confidence: 99%

Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress

et al. 2016

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“…IL-8 is a potent neutrophil chemotactic factor that promotes and prolongs the inflammatory response (31). Wu et al identified that NF-κB also induces the production and release of ICAM-1 (32), which dilates blood vessels, causes the migration of inflammatory cells and induces the release of cytokines and chemokines into adherent tissues. A previous study demonstrated that the expression of VCAM-1, ICAM-1 and NF-κB mRNA in cardiac microvascular endothelial cells in reperfusion injury is suppressed by APS (33).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory effects of Astragalus polysaccharide on EA.hy926 cells

Huang

Liang

Tang

et al. 2013

Experimental and Therapeutic Medicine

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The aim of this study was to explore the role of astragalus polysaccharide (APS) in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm children using an established BPD cell model. EA.hy926 cell cultures were divided into three groups: the air group as the blank control, the hyperoxia group as the experimental control and the APS group (2.5 mg/ml). The production of superoxide dismutase (SOD), malondialdehyde (MDA) and reactive oxygen species (ROS) were analyzed by biochemical assays. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were used to detect the RNA and protein expression levels of inflammatory cytokines, including interleukin (IL)-8, intercellular adhesion molecule 1 (ICAM-1) and nuclear factor (NF)-κB p65. Compared with the hyperoxia group, the ROS and MDA levels of the APS group were significantly reduced. By contrast, SOD production was significantly increased. The expression of IL-8, ICAM-1 and NF-κB p65 in the APS group was downregulated. APS acts as an antioxidant by stimulating SOD production while inhibiting lipid peroxidation in the EA.hy926 cells. Furthermore, this study demonstrated that APS retards the inflammatory response, as shown by the reduced expression of NF-κB p65, IL-8 and ICAM-1 when APS was added.

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“…CRFR1 antagonists have also been utilized in the treatment of inflammatory diseases. Our previous data showed that atherosclerotic lesions in LDLR -/-mice were obviously attenuated by the selective CRFR1 antagonist NBI-27914 when given subcutaneously [20]. We also showed that intraperitoneal injection of NBI-27914 could significantly relieve the signs of intensified ischemia in a rat model of thromboangiitis obliterans [21].…”

Section: Crf-bp In Inflammationmentioning

confidence: 84%

“…Our previous data demonstrated that aerosol inhalation of UCN 1 could increase pulmonary vascular permeability via mast cell infiltration and activation [18], and that mast cell activation and degranulation induced by UCN 1 was mediated by increasing intracellular calcium concentration, which could be blocked by a selective CRFR1 antagonist, but not by a CRFR2 antagonist [19]. Furthermore, it was shown by us that the activation of CRFR1 by CRF induced greater expression of VCAM-1, which contributed to the progression of atherosclerosis in LDL-receptor-deficient mice [20]. Our newly published data also showed that the activation of CRFR1 promoted the development of vasculitis in rats, which was due to the up-regulation of COX-2 and ICAM-1 [21].…”

Section: Crfr1 In Inflammationmentioning

confidence: 84%

Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery?

Zhu

Wang

et al. 2011

Inflamm. Res.

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The corticotropin-releasing factor (CRF) family of neuropeptides is composed of CRF, urocortin 1 (UCN 1), UCN 2 and UCN 3, which can bind to CRF-binding protein (CRF-BP) and two known receptors, CRFR1 and CRFR2, to perform many pathophysiological functions, including inflammation. In contrast to its anti-inflammatory effect in the central nervous system, the roles of the CRF family and its receptors in the periphery are diverse. However, the biological activities of the CRF family in inflammation are circumstantial and remain controversial. It is suggested that this diverse effects of the CRF family may be due to the different types of CRF receptors, different cells and tissues and even different concentrations of CRF family peptides. Though there are difficulties or limitations in establishing the exact modulatory roles of the CRF family and its receptors in peripheral inflammation, the application of CRF receptor agonists or antagonists to treat inflammatory diseases is being pursued with increasing interest. This review describes the effects and mechanisms of the CRF family and its receptors in inflammation; the possible application of CRF receptor agonists or antagonists in inflammatory diseases or disorders will also be discussed.

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Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice

Cited by 23 publications

References 34 publications

Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress

Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress

Antioxidant and anti-inflammatory effects of Astragalus polysaccharide on EA.hy926 cells

Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery?

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