Enhanced extraction of astaxanthin using aqueous biphasic systems composed of ionic liquids and potassium phosphate

Gao, Jing; Fang, Chunli; Lin, Yongzi; Nie, Fang-Hong; Ji, Hongwu; Liu, Shucheng

doi:10.1016/j.foodchem.2019.125672

Cited by 43 publications

(22 citation statements)

References 34 publications

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“…Using an aqueous two-phase system (ATPS), a well-known and highly affordable liquid–liquid extraction technique, can be an impressive method for the extraction and purification of biomolecules − and separation of metal ions, − dyes, − and pharmaceutical compounds. − Besides, it is a simple and low-cost biocompatible extraction method that is efficient for many biological and environmental treatment industries and can be easily scaled up. − Recently, poly(vinyl pyrrolidone) (PVP) has been successfully applied to construct a polymer-salt-based ATPS with many organic and inorganic salts. ,,− It is a water-soluble polymer, inexpensive, and stable and has more features like poly(ethylene glycol) used in biomolecule purification. ,,, Although the PVP is getting the interest of many researchers, a few experimental data were found for the liquid–liquid equilibrium (LLE) data and physical properties of the aqueous mixture of PVP + salt systems.…”

Section: Introductionmentioning

confidence: 99%

Temperature, Polymer Molecular Weight, and Salt Effects on Phase Equilibria of PVP + Formate Salts + Water: Experimental Measurements, Correlations, and Thermodynamic Modeling

2021

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The phase diagram and liquid−liquid equilibrium data for poly(vinyl pyrrolidone) (PVP) of different molecular weights (10,000, 24,000, or 40,000) + potassium formate (KCHO 2 ) or sodium formate (NaCHO 2 ) aqueous two-phase systems were determined experimentally at different temperatures (298.15, 308.15, and 318.15 K). The phase composition and the tie-line ends were obtained by measuring and correlating the density (ρ) and refractive index (n D ) of binary and ternary mixtures within the range of 0−46.6 wt % of PVP and 0−30 wt % of used salts. Furthermore, the binodal data were fitted to both the Pirdashti and Merchuk equations. The cloud point of PVP solutions was determined in the presence of salt at different concentrations. Additionally, the influence of the polymer's molecular weight and temperature on the binodal curve, tie-line length, and slope of tie-line is discussed and compared with the literature data. Moreover, the impact of the Hofmeister series on the separation factor of formate ion was determined. Finally, the extended NRTL and modified UNIFAC-NRF were used to compute the phase compositions of the studied systems, and the adjusted parameters of the models were reported. Results show that both models provide satisfactory agreement with experimental data.

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Section: Introductionmentioning

confidence: 99%

Temperature, Polymer Molecular Weight, and Salt Effects on Phase Equilibria of PVP + Formate Salts + Water: Experimental Measurements, Correlations, and Thermodynamic Modeling

2021

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“…Furthermore, the partitioning of syringic acid was highly related to the DES properties, in which its EE SA value increased with the increase in the phase separation ability of DES/ tert -butanol ABS. Therefore, the ABS containing [Bet][Xyl] and tert -butanol showed a high efficiency in the selective separation of syringic acid and eugenol at 298.15 K. Moreover, mild experimental parameters were needed for the separation of natural biomolecules . The effect of temperature on the partition behaviors of the analytes was studied by using 24.5 wt % of [Bet][Xyl] + 38 wt % of tert -butanol + 37.5 wt % of the H 2 O systems, and the results were described in Figure C,D.…”

Section: Resultsmentioning

confidence: 99%

“…In general, the liquid−liquid equilibrium information obtained as a function of temperature played an important part in the extraction performance of ABS. 29 As a result, the effect of temperature on the efficiency to form DES-based ABS was investigated at 288.15−308.15 K, and described in Figure 3. Detailed binodal curve points were listed in Tables S2−S5.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, the ABS containing [Bet][Xyl] and tert-butanol showed a high efficiency in the selective separation of syringic acid and eugenol at 298.15 K. Moreover, mild experimental parameters were needed for the separation of natural biomolecules. 29 The effect of temperature on the partition behaviors of the analytes was studied by using 24.5 wt % of [Bet][Xyl] + 38 wt % of tert-butanol + 37.5 wt % of the H 2 O systems, and the results were described in Figure 5C,D. It was revealed that the EE SA , EE EG , K SA , and K EG values of syringic acid and eugenol decreased as the temperature increased from 288.15 to 308.15 K, indicating that the hydrophobic interactions between eugenol and tert-butanol may be harmed with the increase of temperature.…”

Section: Methodsmentioning

confidence: 99%

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Pseudoternary Systems of Deep Eutectic Solvents + tert-Butanol + Water at T = 288.15 K, 298.15 K, and 308.15 K: Liquid–Liquid Equilibrium and Ability for Syringic Acid/Eugenol Separation

et al. 2021

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Aiming at developing more biocompatible and economic separation platforms, aqueous biphasic systems (ABS) composed of deep eutectic solvents (DES) and tert-butanol were proposed for the first time. The effects of key factors such as the hydrogen-bond donor (HBD) properties and temperature on the phase-forming ability of DES/tert-butanol ABS were investigated. Meanwhile, syringic acid and eugenol mixtures were selected as model biomolecules to evaluate the efficiency of DES/tert-butanol ABS to use as liquid−liquid extraction systems. The results indicated that DES components migrated preferentially to the bottom phase while tert-butanol was concentrated in the top phase. The more hydrophilic HBD or lower temperature was responsible for greater efficiency to induce the formation of DES/tert-butanol ABS. The reason for phase separation was the incompatibility of the hydrogen-bond acceptor (HBA) and HBD with tert-butanol in aqueous solution, where the higher hydrophilic HBD enriched favorably in the lower phase, allowing for the formation of the DES/tert-butanol ABS. The selective separation of syringic acid and eugenol was a consequence of the HBD characters, temperature, and tie-lines length of the ABS, and they could be greatly separated by using the ABS composed of betaine-xylitol (DES) and tert-butanol at 298.15 K. The highest extraction efficiency of syringic acid and eugenol was 91.64 and 97.62%, respectively. Further, syringic acid and eugenol as well as DES can be recovered and reused by using water as the antisolvent and the vacuum distillation method. This study may be expected to lay a solid foundation for the expansion of DES-based ABS and selective separation of similar biomolecules.

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“…Hence, ionic liquids have found application in very disparate fields, such as organic reaction [ 28 ], electrochemistry [ 29 ], analytical chemistry [ 30 ], pharmaceutics [ 31 ] and chiral electroanalysis [ 32 , 33 ]. In the context of potential distillation enhancers, ionic liquids have been studied with promising results as adjuvants [ 34 ], aqueous biphasic systems [ 35 , 36 ] and hydrotropes [ 37 ] for the extraction of bioactive compounds such as astaxanthin [ 38 ], proanthocyanidins [ 39 ], syringic acid [ 40 ], artemisinin [ 37 ] and so forth.…”

Section: Introductionmentioning

confidence: 99%

Influence of the Use of an Ionic Liquid as Pre-Hydrodistillation Maceration Medium on the Composition and Yield of Cannabis sativa L. Essential Oil

et al. 2021

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Cannabis sativa L. is a multi-purpose crop, whose resilience, adaptability and soil-enriching properties make it a low-impact production. In the last years, the cultivation of the “industrial” hemp varieties (THC < 0.2%) has been promoted by many Countries, opening a whole new market of hemp-derived products, such as its essential oil (EO). Its distillation might represent an effective method to exploit a residue of the hemp fiber production (flowers), complying with the guidelines of the circular economy. In the present work, different concentrations of an ionic liquid (IL; 1,3-dimethyl-1H-imidazol-3-ium dimethylphosphate) have been studied as a pre-hydrodistillation maceration medium. The EO yields have been evaluated, and their compositions have been analyzed by GC-EIMS. The use of 100% and 90% IL concentrations gave a hydrodistillation yield increment of 250% and 200%, respectively. The 200% yield increase was maintained when the 100% IL was recycled after the hydrodistillation. The lower IL concentrations incremented the cannabinoid and oxygenated sesquiterpene contents, while the opposite was true for sesquiterpene hydrocarbons. The proposed IL-enhanced hydrodistillation medium applied to hemp, studied for the first time in the present work, might be used to both (i) noteworthy increment the hydrodistillation yield and (ii) modulate the obtained EO composition based on the desired final product.

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Enhanced extraction of astaxanthin using aqueous biphasic systems composed of ionic liquids and potassium phosphate

Cited by 43 publications

References 34 publications

Temperature, Polymer Molecular Weight, and Salt Effects on Phase Equilibria of PVP + Formate Salts + Water: Experimental Measurements, Correlations, and Thermodynamic Modeling

Temperature, Polymer Molecular Weight, and Salt Effects on Phase Equilibria of PVP + Formate Salts + Water: Experimental Measurements, Correlations, and Thermodynamic Modeling

Pseudoternary Systems of Deep Eutectic Solvents + tert-Butanol + Water at T = 288.15 K, 298.15 K, and 308.15 K: Liquid–Liquid Equilibrium and Ability for Syringic Acid/Eugenol Separation

Influence of the Use of an Ionic Liquid as Pre-Hydrodistillation Maceration Medium on the Composition and Yield of Cannabis sativa L. Essential Oil

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