Enhanced Fumagillin Production by Optimizing Fermentation and Purification Techniques
Zili Feng,
Pengfei Du,
Yunzhi Sheng
et al.
Abstract:Fumagillin is a complex biomolecule. Nowadays, the separation and purification techniques of fumagillin still need to be optimized. In this study, the yield of fumagillin was examined in relation to temperature, pH, inoculation volume, rotation speed, and liquid volume. By using single-factor optimization, a factorial design, and response surface methodology, the fumagillin yield increased from 10~15% to 30~35%. After scaling up the fermentation process, the fumagillin yield remained stable at 30–35%. In addit… Show more
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