Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia

Ding, Yudan; Ou, Yangpan; Su, Qinji; Pan, Pan; Shan, Xiaoxiao; Chen, Jindong; Liu, Feng; Zhang, Zhikun; Zhao, Jingping; Guo, Wenbin

doi:10.3389/fnins.2019.00145

Cited by 34 publications

(20 citation statements)

References 93 publications

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“…Hanford et al 29 suggest this could reflect operation of compensatory processes in higher-performing SZH. Furthermore, enhanced functional connectivity of the left superior frontal gyrus has been put forward as a potential phenotypic marker for the disease: Ding et al 64 found increased functional connectivity specific to the left superior frontal gyrus in both drug-naive SZH and their unaffected siblings; connectivity values of this region could differentiate patients and siblings from controls with good sensitivity, and values did not correlate with symptom severity or illness duration suggesting it could represent a trait marker. However, Ding et al 64 did not assess links with cognition; the current findings suggest this is an important avenue to be explored.…”

Section: Discussionmentioning

confidence: 99%

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

2021

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Cognitive impairments are a core and persistent characteristic of schizophrenia with implications for daily functioning. These show only limited response to antipsychotic treatment and their neural basis is not well characterised. Previous studies point to relationships between cortical thickness and cognitive performance in fronto-temporal brain regions in schizophrenia patients (SZH). There is also evidence that these relationships might be independent of symptom severity, suggesting dissociable disease processes. We set out to explore these possibilities in a sample of 70 SZH and 72 age and gender-matched healthy controls (provided by the Center of Biomedical Research Excellence (COBRE)). Cortical thickness within fronto-temporal regions implicated by previous work was considered in relation to performance across various cognitive domains (from the MATRICS Cognitive Battery). Compared to controls, SZH had thinner cortices across most fronto-temporal regions and significantly lower performance on all cognitive domains. Robust relationships with cortical thickness were found: visual learning and attention performance correlated with bilateral superior and middle frontal thickness in SZH only. Correlations between attention performance and right transverse temporal thickness were also specific to SZH. Findings point to the importance of these regions for cognitive performance in SZH, possibly reflecting compensatory processes and/or aberrant connectivity. No links to symptom severity were observed in these regions, suggesting these relationships are dissociable from underlying psychotic symptomology. Findings enhance understanding of the brain structural underpinnings and possible aetiology of cognitive impairment in SZH.

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Section: Discussionmentioning

confidence: 99%

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

2021

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“…Thus, FC based on the assumptive network of interest may lead to biased results and limits the investigation of the most remarkably altered brain areas that may represent the essential abnormality in the neurobiological mechanisms of OCD (19). Voxel-wise global brain FC (GFC) analysis is a model-free method used to investigate functional interactions across the whole brain regions with an unbiased hypothesis-driven manner, and has been applied to obtain whole brain FC in patients with major depressive disorder (19), schizophrenia (20), and somatization disorder (21).…”

Section: Introductionmentioning

confidence: 99%

Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Cui

Chen

et al. 2020

Front. Psychiatry

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Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise global brain FC (GFC) analysis at rest. Compared with HCs, patients with OCD showed decreased GFC within the default mode network (DMN) (i.e., left posterior cingulate cortex/lingual gyrus) and sensorimotor network (i.e., left precentral gyrus/postcentral gyrus) and increased GFC within the executive control network (ECN) (i.e., left dorsal lateral prefrontal cortex and left inferior parietal lobule). Receiver operating characteristic curve analyses further indicated that the altered GFC values within the DMN, ECN, and sensorimotor network may be used as neuroimaging markers to differentiate patients with OCD from HCs. These findings indicated the aberrant FC patterns of the DMN, ECN, and sensorimotor network associated with the pathophysiology of OCD and provided new insights into the changes in brain organization function in OCD.

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“…The GFC method used in the study is similar to that used in our previous studies (Cui et al, 2018 , 2020 ; Ding et al, 2019 ; Pan et al, 2019a , b ; Li et al, 2020 ). GFC is a measure of functional connectivity of all voxels in the brain with respect to other voxels.…”

Section: Methodsmentioning

confidence: 99%

Reduced Global-Brain Functional Connectivity of the Cerebello-Thalamo-Cortical Network in Patients With Dry Eye Disease

Pan

Wei

et al. 2020

Front. Hum. Neurosci.

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Background: The pathophysiology of patients with dry eye disease (DED) is associated with abnormal functional connectivity (FC). The present study aims to probe alterations of voxel-wise brain-wide FC in patient with DED at rest in an unbiased way. Method: A total of 20 patients with DED and 23 controls matched by age, sex, and years of education underwent resting-state functional magnetic resonance imaging scans. Global-brain FC (GFC) was adopted to analyze the images. Support vector machine (SVM) was utilized to differentiate the patients from the controls. Results: Compared with the controls, patients with DED exhibited decreased GFC in the right cerebellum lobule VIII/inferior semi-lunar lobule and left thalamus that belonged to the cerebello-thalamo-cortical network. The GFC values in the left thalamus were positively correlated to the illness duration (r = 0.589, p = 0.006) in the patients. Decreased GFC values in the left thalamus could be used to discriminate the patients from the controls with optimal accuracy, sensitivity and specificity (88.37, 85.00, and 91.30%). Conclusions: Our findings indicate that decreased GFC in the brain regions associated with cerebello-thalamo-cortical network may provide a new insight for understanding the pathological changes of FC in DED. GFC values in the left thalamus may be utilized as a potential biomarker to identify the patients from the controls.

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Enhanced Global-Brain Functional Connectivity in the Left Superior Frontal Gyrus as a Possible Endophenotype for Schizophrenia

Cited by 34 publications

References 93 publications

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder

Reduced Global-Brain Functional Connectivity of the Cerebello-Thalamo-Cortical Network in Patients With Dry Eye Disease

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