Enhanced hemocompatibility and antibacterial activity of biodegradable poly(ester-urethane) modified with quercetin and phosphorylcholine for durable blood-contacting applications

Hao, Tiantian; Niu, Guangliang; Zhang, Hao; Zhu, Yuzheng; Zhang, Chunxia; Kong, Fanzhao; Xu, Jing; Hou, Zhaosheng

doi:10.1039/d3tb00596h

Cited by 7 publications

(1 citation statement)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To deal with the challenge of secondary biofilm formation, a proactive approach involves impeding the initial bacterial adhesion to the surface. Numerous investigations have focused on prohibiting bacterial attachment through the creation of a hydration layer, achieved using materials such as poly(ethylene glycol) (PEG) and zwitterionic compounds. − …”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifogging Nanopillar Array Films: Targeted Efficacy against Staphylococcus aureus

Kim,

Han,

Cho

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Staphylococcus aureus (S. aureus) is a common bacterium that can cause a wide range of infections in humans. The growth of these bacteria is inhibited by strategies using antibiotics and/or nanomaterials. However, nanomaterials and antibiotics can cause cytotoxicity and antibiotic resistance. Recent research has focused on achieving mechanical inhibition of bacterial growth through the surface nanostructure. Antibacterial use of nanostructured surfaces does not need antibiotics. Meanwhile, transparent films are necessary in the medical, optical, and automotive industries. In this study, we proposed a flexible, transparent, antibacterial, and antifogging film with a nanostructured surface. The bactericidal and bacteriostatic effects were observed on the arrayed nanopillars according to spacing. For S. aureus, bactericidal effect was observed at a nanopillar spacing of 300 nm, and bacteriostatic effect was observed at 500−1000 nm. Furthermore, the antibacterial rate was improved by 94.9% through MPC polymer coating at the surface. In addition, the MPC coating maintained an antibacterial rate of 86.6 and 64.1% for 7 and 14 days, respectively. The hydrophilic MPC-coated surface has properties of antifogging and transparency for potential usage in optical devices. This study provides insight into the potential of nanostructured surfaces using a dual strategy to prevent bacterial infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifogging Nanopillar Array Films: Targeted Efficacy against Staphylococcus aureus

Kim,

Han,

Cho

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

show abstract

Structural insights and biological activities of flavonoids: Implications for novel applications

Tang,

Wang,

Liu

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering considerable attention. Notably, the physicochemical properties and functionalities of flavonoids are structurally dependent. Variations in chemical structure lead to differences in physicochemical characteristics among different flavonoid types. Structural alterations can modify these characteristics, influencing biological activities and mechanisms of action. However, these structural variations and their biological implication have not been comprehensively elucidated. In this review, we outline the structural characteristics of flavonoids, discuss biosynthesis, in vivo digestion, and absorption, and particularly emphasize the diverse biological activities and action mechanisms associated with different flavonoid structures. By summarizing the current scientific findings, we aim to elucidate the structure–activity relationships of flavonoids and provide a theoretical basis for the development of new flavonoid applications, which will help to target the design of functional molecules and moieties in the food and pharmaceutical industries for use in drug design and development.Practical Application: Understanding the structural characteristics and biological activities of flavonoids can guide the development of functional food products and dietary supplements with targeted health benefits. By leveraging the knowledge of flavonoid structure–activity relationships, food, and pharmaceutical industries can innovate formulations to enhance bioavailability and efficacy, potentially leading to the creation of tailored products for specific health conditions or dietary needs. This research lays the groundwork for the design of novel flavonoid‐based interventions aimed at promoting human health and well‐being.

show abstract

Multifunctional poly(ether‐urethane) elastomer based on dynamic phenol-urethane and disulfide bonds: Simultaneously showing superior toughness, self-healing, shape memory, antibacterial, and antioxidative properties

Hao,

Gao,

Zheng

et al. 2024

European Polymer Journal

View full text Add to dashboard Cite

Enhanced hemocompatibility and antibacterial activity of biodegradable poly(ester-urethane) modified with quercetin and phosphorylcholine for durable blood-contacting applications

Abstract: This work developed innovative poly(ester-urethane) materials double-modified by quercetin (QC) and phosphorylcholine (PC) with improved antibacterial activity and hemocompatibility. The functional monomer of PC-diol was firstly synthesized via click reaction...

Cited by 7 publications

References 59 publications

Antibacterial and Antifogging Nanopillar Array Films: Targeted Efficacy against Staphylococcus aureus

Antibacterial and Antifogging Nanopillar Array Films: Targeted Efficacy against Staphylococcus aureus

Structural insights and biological activities of flavonoids: Implications for novel applications

Multifunctional poly(ether‐urethane) elastomer based on dynamic phenol-urethane and disulfide bonds: Simultaneously showing superior toughness, self-healing, shape memory, antibacterial, and antioxidative properties

Contact Info

Product

Resources

About