Enhanced IκB kinase activity is responsible for the augmented activity of NF-κB in human head and neck carcinoma cells

Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells

“…IKKb is one of the catalytic subunits of the IKK complex that has been shown to be crucial for the NFkB-mediated production of proinflammatory cytokines that are related to cell survival and cell proliferation Hu et al, 2004), and has been found highly active in many types of cancer (Ludwig et al, 2001;Romieu-Mourez et al, 2001;Tamatani et al, 2001;Yang and Richmond, 2001;Baumgartner et al, 2002;Li et al, 2004). Consistent with these findings, we observed a correlation between IKKb expression levels, NK-kB activity and cytokine production.…”

“…Although IKKa is more important in cell differentiation, lymphoid organogenesis and the regulation of adaptive immunity (Hacker and Karin, 2006;Liu et al, 2006), IKKb is crucial for the production of proinflammatory cytokines that are related to cell survival and cell proliferation Hu et al, 2004). IKKb has been found highly active in many different types of cancer including breast cancer, pancreatic cancer, thyroidal C-cells carcinoma, melanoma and acute myeloid leukemia (Ludwig et al, 2001;Romieu-Mourez et al, 2001;Tamatani et al, 2001;Yang and Richmond, 2001;Baumgartner et al, 2002;Li et al, 2004). IKKb deletion in mouse enterocytes decreased the incidence of colitisassociated tumor by 75% .…”

Anticancer agent CHS 828 suppresses nuclear factor‐κB activity in cancer cells through downregulation of IKK activity

“…29 The constitutive NF-B activation has also been observed in human prostate cancer cells 30 and in head and neck carcinoma cells. 31 Our observation that CHS 828 targets the NF-B pathway could provide an explanation for why cancer cells are more sensitive to the compound than normal cells.…”

CXCL12/SDF‐1α Activates NF‐κB and Promotes Oral Cancer Invasion through the Carma3/Bcl10/Malt1 Complex

“…Consitutive activation of NF-κB is also observed in many human tumors including OSCC (Tamatani et al, 2001;Jackson-Bernitsas et al, 2007;Sethi et al, 2008). We previously investigated the role of the NF-κB signaling pathway in OSCC and found that SDF-1α can activate NF-κB specifically through the CXCR4 receptor to induce invasion of OSCC.…”