Enhanced mechanical performance and bioactivity in strontium/copper co-substituted diopside scaffolds

Pang, Shumin; Wu, Dong; Yang, Haotian; Kamutzki, Franz; Kurreck, Jens; Gurlo, Aleksander; Hanaor, Dorian

doi:10.1016/j.bioadv.2022.213230

Cited by 9 publications

(3 citation statements)

References 57 publications

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“…[12][13][14][15] Pang et al, prepared strontium and copper doped diopside, which showed mechanical improvement, superior bioactivity and strong osteogenic effect on bone cells. 12 Shen et al, fabricated a core-shell structure wollastonite@diopside scaffolds that were presented with both mechanical and biodegradable properties. 13 Ros-Tarraga and coworkers prepared diopside-wollastonite eutectic ceramics.…”

Section: Introductionmentioning

confidence: 99%

“…Considering diopside (i.e., CaMgSi 2 O 6 ; CMS), several studies have shown that incorporating certain ions or other bioceramic materials signicantly improved both physical and biological properties. [12][13][14][15] Pang et al, prepared strontium and copper doped diopside, which showed mechanical improvement, superior bioactivity and strong osteogenic effect on bone cells. 12 Shen et al, fabricated a core-shell structure wollastonite@diopside scaffolds that were presented with both mechanical and biodegradable properties.…”

Section: Introductionmentioning

confidence: 99%

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Investigation on the physical properties and biocompatibility of zirconia–alumina-silicate@diopside composite materials and its in vivo toxicity study in embryonic zebrafish

Rittidach,

Sillapaprayoon,

Chantho

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation on the physical properties and biocompatibility of zirconia–alumina-silicate@diopside composite materials and its in vivo toxicity study in embryonic zebrafish

Rittidach,

Sillapaprayoon,

Chantho

et al. 2023

RSC Adv.

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“…Particle fusion also leads to the formation of loose aggregates. 49 , 50 However, because of the dense formed clusters of both pure and doped HA particles, determining the size of a single particle was challenging. Spherical powders offer higher rheological qualities than irregular powders and less cytotoxicity than needle and plate shaped nanohydroxyapatite, making them ideal for medical applications.…”

Section: Resultsmentioning

confidence: 99%

Selenium- and/or copper-substituted hydroxyapatite: A bioceramic substrate for biomedical applications

Korowash,

Keskin-Erdogan,

Hemdan

et al. 2023

J Biomater Appl

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Atomic substitution or doping of a bioceramic material hydroxyapatite (HA) with specific ions is an appealing approach for improving its biocompatibility and activity, as well as imparting antibacterial properties. In this study, selenium- and/or copper-substituted hydroxyapatite powders were synthesized by an aqueous precipitation method and using the freeze-drying technique. The molar concentrations of constituents were calculated based on the proposed mechanism whereby selenium (Se4+) ions partially substitute phosphorus (P5+) sites, and copper (Cu2+) ions partially substitute (Ca2+) sites in the HA lattice. Dried precipitated samples were characterized using Inductively coupled plasma optical emission spectroscopy (ICP-OES), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FTIR) and Field-emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX). Accordingly, substitution of Se4+ and/or Cu2+ ions took place in the crystal lattice of HA without the formation of any impurities. The presence of sulphur (S2-) ions in the hydroxyapatite was detected by ICP-OES in all samples with copper substituted in the lattice. The cytotoxicity of the powders on osteoblastic (MC3T3-E1) cells was evaluated in vitro. Selenium substituted hydroxyapatite (SeHA), at the concentration (200 μg/mL), demonstrated higher populations of the live cells than that of control (cells without powders), suggesting that selenium may stimulate the proliferation of these cells. In addition, the copper substituted hydroxyapatite (CuHA) and the selenium and copper substituted hydroxyapatite (SeCuHA) at the concentrations (200 and 300 μg/mL) and (200 μg/mL), respectively demonstrated better results than the unsubstituted HA. Antimicrobial activity was assessed using a well-diffusion method against Streptococcus mutans and Candida albicans, and superior results has obtained with SeCuHA samples. Presented findings imply that selenium and/or copper substituted modified hydroxyapatite nanoparticles, may be an attractive antimicrobial and cytocompatible substrate to be considered for use in a range of translational applications.

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Editorial 3D bioprinting and advanced biofabrication of biomaterials

Ouyang,

Salmeron-Sanchez

2024

Biomaterials Advances

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Enhanced mechanical performance and bioactivity in strontium/copper co-substituted diopside scaffolds

Cited by 9 publications

References 57 publications

Investigation on the physical properties and biocompatibility of zirconia–alumina-silicate@diopside composite materials and its in vivo toxicity study in embryonic zebrafish

Investigation on the physical properties and biocompatibility of zirconia–alumina-silicate@diopside composite materials and its in vivo toxicity study in embryonic zebrafish

Selenium- and/or copper-substituted hydroxyapatite: A bioceramic substrate for biomedical applications

Editorial 3D bioprinting and advanced biofabrication of biomaterials

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