The degradation of eight pesticides was evaluated In a soil pretreated with their respective hydrolysis metabolites. 2,4-Dlchlorophenol, p-nltrophenol, and salicylic acid conditioned the soil for enhanced degradation of 2,4-dlchlorophenoxyacetlc acid (2,4-D), parathlon, and Isofenphos, respectively. Repeated application of carbofuran phenol, 2-lsopropyl-4-methyl-6-hydroxypyrlmldlne, methyl phenyl sulfone, thlophenol, Isopropyl salicylate, and 2,4,5trlchlorophenol had no effect on the rate of degradation of their parent pesticides. Prior exposure of soil to 3,5,6-trlchloro-2-pyrldlnol resulted In Increased persistence of Its parent compound, chlorpyrlfos. Results Indicate that pesticide hydrolysis metabolites can affect the Induction or Inhibition of enhanced microbial degradation of some sollapplled pesticides.