Enhanced mid-infrared multi-bounce ATR spectroscopy for online detection of hydrogen peroxide using a supercontinuum laser

Gasser, Christoph; Kilgus, Jakob; Harasek, Michael; Lendl, Bernhard; Brandstetter, Markus

doi:10.1364/oe.26.012169

Cited by 36 publications

(20 citation statements)

References 33 publications

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“…There is ongoing work on the development of supercontinuum sources in the NIR and moving to longer wavelengths; 324-328 although these are not portable at the present time, there are continuing investigations for their applications to spectroscopy, [329][330][331][332][333] including in the mid-IR. [334][335][336] Optical parametric oscillators (OPOs) 337 are another example of a broadly tunable laser-based source 338 and these have been used in laboratory spectroscopic imaging studies, 339 but are not available in a form suitable for a portable instrument.…”

Section: Tunable and Laser Sourcesmentioning

confidence: 99%

Portable Spectroscopy

Crocombe¹

2018

Appl Spectrosc

403

233

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Until very recently, handheld spectrometers were the domain of major analytical and security instrument companies, with turnkey analyzers using spectroscopic techniques from X-ray fluorescence (XRF) for elemental analysis (metals), to Raman, mid-infrared, and near-infrared (NIR) for molecular analysis (mostly organics). However, the past few years have seen rapid changes in this landscape with the introduction of handheld laser-induced breakdown spectroscopy (LIBS), smartphone spectroscopy focusing on medical diagnostics for low-resource areas, commercial engines that a variety of companies can build up into products, hyphenated or dual technology instruments, low-cost visible-shortwave NIR instruments selling directly to the public, and, most recently, portable hyperspectral imaging instruments. Successful handheld instruments are designed to give answers to non-scientist operators; therefore, their developers have put extensive resources into reliable identification algorithms, spectroscopic libraries or databases, and qualitative and quantitative calibrations. As spectroscopic instruments become smaller and lower cost, ''engines'' have emerged, leading to the possibility of being incorporated in consumer devices and smart appliances, part of the Internet of Things (IOT). This review outlines the technologies used in portable spectroscopy, discusses their applications, both qualitative and quantitative, and how instrument developers and vendors have approached giving actionable answers to non-scientists. It outlines concerns on crowdsourced data, especially for heterogeneous samples, and finally looks towards the future in areas like IOT, emerging technologies for instruments, and portable hyphenated and hyperspectral instruments.

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Section: Tunable and Laser Sourcesmentioning

confidence: 99%

Portable Spectroscopy

Crocombe¹

2018

Appl Spectrosc

403

233

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“…Developing accurate, sensitive, rapid and selective methods to detect the concentration of H 2 O 2 , a normal oxidative stress biomarker, will be undoubtedly beneficial to the early diagnosis. Up to now, a host of analytical methods such as spectroscopy [6], colorimetry [7], fluorescence [8,9] and electrochemical methods [10][11][12] have been applied in H 2 O 2 determination. Electrochemical method, especially amperometric test is gradually becoming one of the most simple and effective detection methods for H 2 O 2 biological analysis among diverse sensing methods due to its advantages such as high sensitivity, outstanding selectivity and low cost.…”

Section: Introductionmentioning

confidence: 99%

Cobalt Phosphide (Co2P) with Notable Electrocatalytic Activity Designed for Sensitive and Selective Enzymeless Bioanalysis of Hydrogen Peroxide

et al. 2021

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In this work, cobalt phosphide nanoparticles (Co2P NPs) were prepared by simple and mild hydrothermal method without the use of harmful phosphorous source. The morphological structure and surface component of Co2P were characterized by transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy measurements. Considering the excellent electrocatalytic reduction activity and good electrical conductivity of transition-metal phosphide, we fabricated Co2P NPs on indium tin oxide (ITO) substrate (Co2P/ITO) for H2O2 detection. The Co2P/ITO transducer displayed a rapid amperometric response less than 5 s, a broader response range from 0.001 to 10.0 mM and a low detection limit of 0.65 μM. In addition, the non-enzymatic Co2P/ITO sensor showed outstanding selectivity, reproducibility, repeatability and stability, all of which qualified the Co2P/ITO electrode for quite a reliable and promising biosensor for H2O2 sensing.

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“…6,7 The noise characteristics of supercontinuum generation, which had been a deterrent in their early days, were significantly improved since then. 8,9,5 Successful demonstrations of mid-IR supercontinuum based setups in a wide variety of noise sensitive applications [10][11][12][13][14][15] prove their practical suitability. Furthermore, it is expected that the trend of noise reduction will continue, e.g., by implementing the supercontinuum generation in an all-normal-dispersion regime, which is insensitive to the input pump noise delivering the enhanced shot-to-shot spectral coherence.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity-Enhanced Fourier Transform Mid-Infrared Spectroscopy Using a Supercontinuum Laser Source

et al. 2020

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Fourier transform infrared (FT-IR) spectrometers have been the dominant technology in the field of mid-infrared (mid-IR) spectroscopy for decades. Supercontinuum laser sources operating in the mid-IR spectral region now offer the potential to enrich the field of FT-IR spectroscopy due to their distinctive properties, such as high-brightness, broadband spectral coverage and enhanced stability. In our contribution, we introduce this advanced light source as a replacement for conventional thermal emitters. Furthermore, an approach to efficient coupling of pulsed mid-IR supercontinuum sources to FT-IR spectrometers is proposed and considered in detail. The experimental part is devoted to pulse-to-pulse energy fluctuations of the applied supercontinuum laser, performance of the system, as well as the noise and long-term stability. Comparative measurements performed with a conventional FT-IR instrument equipped with a thermal emitter illustrate that similar noise levels can be achieved with the supercontinuum-based system. The analytical performance of the supercontinuum-based FT-IR spectrometer was tested for a concentration series of aqueous formaldehyde solutions in a liquid flow cell (500 µm path length) and compared with the conventional FT-IR (130 µm path length). The results show a four-times-enhanced detection limit due to the extended path length enabled by the high brightness of the laser. In conclusion, FT-IR spectrometers equipped with novel broadband mid-IR supercontinuum lasers could outperform traditional systems providing superior performance, e.g., interaction path lengths formerly unattainable, while maintaining low noise levels known from highly stable thermal emitters.

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Enhanced mid-infrared multi-bounce ATR spectroscopy for online detection of hydrogen peroxide using a supercontinuum laser

Cited by 36 publications

References 33 publications

Portable Spectroscopy

Portable Spectroscopy

Cobalt Phosphide (Co2P) with Notable Electrocatalytic Activity Designed for Sensitive and Selective Enzymeless Bioanalysis of Hydrogen Peroxide

Sensitivity-Enhanced Fourier Transform Mid-Infrared Spectroscopy Using a Supercontinuum Laser Source

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