Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells

Patil, Sharvil; Choudhary, Bhavana; Rathore, Atul; Roy, Krishtey; Mahadik, Kakasaheb R.

doi:10.1016/j.phymed.2015.08.006

Cited by 100 publications

(41 citation statements)

References 23 publications

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“…The inhibition of efflux transporters by the excipient used in the formulation, however, is more likely to enhance the biological availability and activity of curcumin rather than reducing its efficacy. Accordingly, improved oral bioavailability and inhibition of P‐glycoprotein (ATP‐binding cassette transporter B1) has been reported for (nonpolysorbate 80) mixed micelles .…”

Section: Discussionmentioning

confidence: 99%

Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals

Kocher

Bohnert

Schiborr

et al. 2016

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 99%

Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals

Kocher

Bohnert

Schiborr

et al. 2016

Molecular Nutrition Food Res

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“…Dried microspheres were accurately weighed, and considering the total amount of drug and polymers used for preparing the feed solution, the process yield was calculated, a using following formula [10].…”

Section: Process Yieldmentioning

confidence: 99%

Formulation Andcharacterization of Olanzepineloaded Mucoadhesive Microspheres

Deshmukh¹,

Mohite²

2017

Asian J Pharm Clin Res

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Objective: The objective of this research was to formulate and evaluate olanzapine (OLE) mucoadhesive microsphere prepared using carbopol and sodium combination. OLE having extensive hepatic first pass metabolism and low bioavailability problem, determined the need for the development of sustained release formulation.Methods: OLE mucoadhesive microspheres were prepared by ionic gelation method. OLE mucoadhesive microspheres were prepared by ionic gelation method by using calcium chloride as crosslinking agent. The OLE mucoadhesive microsphere was characterized by particle size measurement, process yield, morphology of microsphere, drug entrapment efficiency, mucoadhesion test, differential scanning calorimetry, powder X-ray diffraction, Fourier transforms infrared (FTIR) study and in-vitro drug release. Results:The OLE mucoadhesive microsphere having mean particle size ranged from 546.0 µm to 554.3 µm, and the entrapment efficiencies ranged from 73% to 96%. All the olanzapine (OLE) microsphere batches showed good in-vitro mucoadhesive property ranging from 75.89% to 96.47% and in the in-vitro wash off test ranging from 68.12% to 81.3%. FTIR studies indicated the no drug-polymer interactions in the ideal formulation F9. There were no compatibility issues, and the crystallinity of OLE was found to be reduced shoeing less intense peak in prepared mucoadhesive microspheres, which were confirmed by differential scanning calorimeter and X-ray diffraction studies. Among different formulations, the OLE microspheres of batch F9 had shown the optimum percent drug entrapment of microspheres. Release pattern of OLE from F9 microspheres batch followed Higuchi kinetic model. Stability studies were carried out for F9 formulation at 4°C/ambient, 25±2°C/60±5%, 40±2°C/75±5% relative humidity revealed that the drug entrapment, mucoadhesive behavior, and drug release were within permissible limits. Conclusion:The results obtained in this work demonstrate the use of carbopol and sodium alginate polymer for preparation of mucoadhesive microsphere.

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“…The rate and the mechanism of release of olanzapine from the prepared mucoadhesive microspheres were analyzed by fitting the dissolution data into various kinetic models like zero order; first order, Higuchi's model and coefficient of correlation (r) values were calculated for the linear curves by regression analysis of the above plots. [14][15] 2.10. Fourier transforms infrared spectroscopy (FTIR) studies Infrared spectra for pure Olanzapine and for the physical mixture of Olanzapine and polymer was determined to check the intactness of the drug in the polymer mixture using FTIR -Spectrophotometer.…”

Section: Release Kinetic Studiesmentioning

confidence: 99%

Formulation and Evaluation of Olanzepine Microspheres.

Deshmukh¹,

Mohite²

2017

JCPR

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The aim of this research was to formulate and evaluate mucoadhesive microspheres of Olanzapine drug to enhance bioavailability and enhance residence time. Olanzepine mucoadhesive microsphere prepared by using sodium alginate polymer and calcium chloride as a crosslinking agent. .Microsphere were prepared by using ionic gelation method. Microsphere with particle size in the range 656.4µm to 659 µm. were prepared by using ionic gelation method. Olanzapine (OLE) having extensive hepatic first pass metabolism and low bioavailability problem, Olanzapine microspheres were evaluated for mean particle size, the percentage yield, entrapment efficiencies, in-vitro release, in vitro mucoadhesive, FTIR, DSC, X-ray diffraction studies and stability study. Formulation F9 microspheres batch was found to be optimized and followed zero-order release kinetic .The optimized formulation was mucoadhesive in nature. Stability studies was carried out for F9 at a temperature of 40±2°C/ RH 75±5% formulation revealed that the drug behavior was within permissible limits.

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Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells

Cited by 100 publications

References 23 publications

Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals

Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals

Formulation Andcharacterization of Olanzepineloaded Mucoadhesive Microspheres

Formulation and Evaluation of Olanzepine Microspheres.

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