Enhanced protective efficacy against tuberculosis provided by a recombinant urease deficient BCG expressing heat shock protein 70-major membrane protein-II having PEST sequence

Tsukamoto, Yumiko; Maeda, Yosuke; Tamura, Toshiki; Mukai, T.; Mitarai, Satoshi; Yamamoto, Saburo; Makino, Masahiko

doi:10.1016/j.vaccine.2016.10.069

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Thereinto, HSP70 is the most conserved among HSPs, ubiquitous existence in almost all organisms. HSP70 has been recognized as an immunodominant antigen during infections caused by Plasmodium yoelii (Sanchez et al., ), Brugia malayi (Dakshinamoorthy et al., ), Leishmania donovani (Kaur, Sobti, & Kaur, ) and some other pathogens (Czarnewski, Araújo, Oliveira, Mineo, & Silva, ; Tsukamoto et al., ; Verma, Batra, & Tuteja, ). The recombinant T. spiralis HSP70 can activate DC maturation with the characteristic of secretion of IL‐1β, IL‐12p70, TNF‐α and IL‐6 productions, which contributed to reduce more than 37% muscle larval loading in mice compared to the controls (Fang et al., ; Wang et al., ).…”

Section: Candidate Antigensmentioning

confidence: 99%

Vaccines againstTrichinella spiralis: Progress, challenges and future prospects

Zhang

2018

Transbound Emerg Dis

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Trichinella spiralis, the causative agent of trichinellosis, is able to infect a wide range of carnivores and omnivores including human beings. In the past 30 years, a mass of vaccination efforts has been performed to control T. spiralis infection with the purpose of reduction in worm fecundity or decrease in muscle larval and adult burdens. Here, we summarize the development of veterinary vaccines against T. spiralis infection. During recent years, increasing numbers of new vaccine candidates have been developed on the protective immunity against T. spiralis infection in murine model. The vaccine candidates were not only selected from excretory-secretory (ES) antigens, but also from the recombinant functional proteins, such as proteases and some other antigens participated in T. spiralis intracellular processes. However, immunization with a single antigen generally revealed lower protective effects against T. spiralis infection in mice compared to that with the inactivated whole worms or crude extraction and ES productions. Future study of T. spiralis vaccines should focus on evaluation of the protective efficacy of antigens and/or ligands delivered by nanoparticles that could elicit Th2-type immune response on experimental pigs.

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