Enhanced ROS-Generation in Lymphocytes from Alzheimer’s Patients

Leutner, Silke; Schindowski, Katharina; Frölich, L.; Maurer, K.; Kratzsch, Tilman; Eckert, Anne; Müller, Wernér E.G.

doi:10.1055/s-2005-916186

Cited by 45 publications

(35 citation statements)

References 21 publications

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“…Firstly, lymphocytes of AD patients have increased basal ROS levels and secondly they react differently to oxidative stressors like staurosporine. They show increased levels of ROS after the treatment with staurosporine (Leutner et al, 2005). Our findings are supported by results of altered levels and activities of antioxidant enzymes.…”

Section: Increased Spontaneous Apoptosis In Cd4supporting

confidence: 90%

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease

Leuner

Pantel

Frey

et al. 2007

Neuropsychiatric Disorders an Integrative Approach

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Summary Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will increase with increased life expectancy. The AD brain is marked by severe neurodegeneration like the loss of synapses and neurons, atrophy and depletion of neurotransmitter systems in the hippocampus and cerebral cortex. Recent findings suggest that these pathological changes are causally induced by mitochondrial dysfunction, increased oxidative stress and elevated apoptosis. Until now, AD cannot be diagnosed by a valid clinical method or a biomarker before the disease has progressed so far that dementia is present. Furthermore, no valid method is available to determine which patient with mild cognitive impairment (MCI) will progress to AD. Therefore, a correct diagnosis in the early stage of AD is not only of importance considering that early drug treatment is more effective but also that the psychological burden of the patients and relatives could be decreased. In this review, we discuss the potential role of elevated apoptosis, increased oxidative stress and mitochondrial dysfunction as biomarker for AD in a peripheral cell model, the lymphocytes.

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Section: Increased Spontaneous Apoptosis In Cd4supporting

confidence: 90%

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease

Leuner

Pantel

Frey

et al. 2007

Neuropsychiatric Disorders an Integrative Approach

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“…Leutner el al. [29] have founded enhanced ROSgeneration in lymphocytes from Alzheimer's disease. An increase in markers of lipid peroxidation and a decrease in antioxidants have been detected by Rinaldi et al [30] in plasma.…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias

et al. 2007

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It has been reported that oxidative stress may play a role in the pathogenesis of dementia of the Alzheimer type (AD) and the cerebral ischemia which causes vascular dementia (VD). We measured malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities in blood samples from patients with AD and VD and in healthy non-demented controls (CTR) which similar ages to the patients, in order to evaluate the degree of oxidative stress in patients with AD and VD. A sample of 150 subjects consisting of 50 patients with AD; 50 patients with VD and 50 CTR, aged from 65 to 85 years on, was analyzed. Most of the changes observed were in SOD activity and MDA levels. Catalase activity were least affected. Significant differences were observed in SOD and GR activity between males and females in CRT and in patients with AD, but not in VD. We have found a decrease in antioxidant enzymes activities (SOD, CAT, GPx and GR) in patients with AD and VD and significant differences were observed between CRT and AD patients for ages from 65 to 74, 75 to 84 and from 85 years to 94 years in SOD activity and MDA levels (P < 0.001). MDA levels increase with age in VD, AD and CTR. No significant variation with respect to sex were detected, but significant variations in MDA levels were detected between CRT and patients with VD and AD (P < 0.001). We conclude that oxidative stress plays an important role in the brain damage for both AD and VD, being observed higher levels of oxidative stress for AD that for VD.

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“…The GSH antioxidant system is the body's powerhouse for diffusing and disposing the radicals that threaten the cell and tissue and cause organ damage, thus slowing the approach of age [20]. One of the several possibilities for the occurrence of a lower GSH conc.…”

Section: Resultsmentioning

confidence: 99%

The Oxidative Stress in Cataract Patients

Kaur¹

2012

JCDR

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Background: The recent studies on cataract formation focus on the primary role of the systemic oxidative stress which is generated outside the lens. Our research was directed to assess the oxidative stress by measuring the lipid peroxidation products in the form of the Thiobarbituric Acid Reactive Substances (TBARS) and the antioxidant enzyme levels in the blood. The antioxidant therapy may have a role to play in delaying the onset and the progression of age related cataracts. Material and Method:This was a case control study. It comprised of 100 age matched subjects (50 with cataracts and 50 controls) with their ages ranging from 45-75 years. Oxidative stresses such as the Thiobarbituric Acid Reactive Substances (TBARS) and the antioxidant enzymes, Superoxide Dismutase (SOD) and Glutathione Peroxidase( GPX ) were investigated in all the patients and the controls.Results: Significantly increased levels of serum lipid peroxide in the form of Malondialdehyde (MDA ) (p<0.001) were observed in the cataract patients as compared to the controls. Significantly decreased blood levels of SOD and GPX were observed in all the patients. Conclusion:In the present study, it was concluded that oxidative stress plays an important role in the onset and the progression of cataracts. The pro-oxidant i.e. serum malondialdehyde (MDA) levels were increased in the cataract patients. The blood levels of the enzymatic anti-oxidants, SOD and GPX were decreased. The plasma TBARS can be used as biomarkers of the degeneration in the lens.JasKiran Kaur, sahiba KuKreJa, amandeep Kaur, naresh malhotra, ravneet Kaur

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Enhanced ROS-Generation in Lymphocytes from Alzheimer’s Patients

Cited by 45 publications

References 21 publications

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer’s disease

Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias

The Oxidative Stress in Cataract Patients

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