2009
DOI: 10.3892/or_00000404
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Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

Abstract: Abstract.To investigate the expression levels of S100A4 in human colorectal carcinoma (CC) and its relationship with clinicopathological parameters and metastatic potential, 73 pathological specimens from patients with CC were examined for S100A4 expression by RT-PCR and immunohistochemistry. An increase of S100A4 mRNA was observed in 19/23 (82.6%) CC specimens, and S100A4 was up-regulated in 40/73 (54.7%) CC cases compared with non-neoplastic mucosal tissues. Upregulation of S100A4 was significantly related t… Show more

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Cited by 17 publications
(16 citation statements)
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“…S100A4 has been demonstrated to act as a metastasis-inducing gene [17], [42], [43]. Furthermore, S100A4 has been shown to be a prognostic biomarker when determined in colorectal cancer tissues by qRT-PCR and immunohistochemistry [16], [44]–[48]. We have recently demonstrated the diagnostic and prognostic value of circulating S100A4 transcripts in colorectal cancer and in gastric cancer patients [18].…”
Section: Discussionmentioning
confidence: 99%
“…S100A4 has been demonstrated to act as a metastasis-inducing gene [17], [42], [43]. Furthermore, S100A4 has been shown to be a prognostic biomarker when determined in colorectal cancer tissues by qRT-PCR and immunohistochemistry [16], [44]–[48]. We have recently demonstrated the diagnostic and prognostic value of circulating S100A4 transcripts in colorectal cancer and in gastric cancer patients [18].…”
Section: Discussionmentioning
confidence: 99%
“…The prognostic role of S100A4 expression remains controversial in colorectal cancer 11, 21–24, 28, 29. These discrepancies could arise from subtle variations in the number of patients, observation period, stage distribution, tissue fixation methods, use of antibodies, and cutoff of positivity.…”
Section: Discussionmentioning
confidence: 99%
“…It has been linked to the invasive growth and metastasis of several human solid cancers, and the possible mechanisms in this linkage have been reviewed [1][2][3]. In colorectal cancer, the association between S100A4 and factors related to progression of the tumour has been examined by several authors [4][5][6][7][8], leading to the suggestion that overexpression of this protein may be related to survival and could therefore be a useful prognostic or predictive marker.…”
mentioning
confidence: 99%